壳聚糖的理化性质及其在生物医学领域的应用研究

IF 3.4 4区 化学 Q2 POLYMER SCIENCE
Digafe Alemu, Efrata Getachew, A. Mondal
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引用次数: 0

摘要

壳聚糖是由几丁质去乙酰化而成的天然聚合物。它主要来源于甲壳类动物和真菌。它具有生物相容性、可生物降解性、阳离子性和无毒性等特性。壳聚糖的这些特性使其成为一种具有广泛应用价值的材料。此外,这些独特的特性在生物医学上有重要的应用,如药物输送、组织工程、抗菌剂和伤口愈合。然而,它也有其缺点,如原料来源季节性和地方性,提取过程耗时,成本高,涉及大量刺激性化学品的使用,以及从海洋来源获得的壳聚糖质量不稳定。此外,还需要研究如何提高壳聚糖的收率和在各种工业用途上的利用。基因修饰等技术改进将提高壳聚糖的产量和应用。本文主要综述了壳聚糖在组织工程、伤口敷料、给药等生物医学领域的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study on the Physicochemical Properties of Chitosan and their Applications in the Biomedical Sector
Chitosan is a natural polymer derived from the deacetylation of chitin. It is mainly derived from crustaceans and fungal sources. It has many intrinsic properties, such as biocompatibility, biodegradability, cationic nature, and nontoxicity. These features of chitosan have made it an attractive material for various applications. Furthermore, these unique properties have found significant biomedical applications, such as in drug delivery, tissue engineering, antimicrobial agent, and wound healing. However, it has its drawbacks, such as the raw material source being seasonal and localized, the extraction procedure being time-consuming, costly, and involving the use of harsh chemicals in substantial amounts, and the quality of chitosan obtained from marine sources being variable. Furthermore, studies are needed to increase the yield and utilization of chitosan for various industrial purposes. Technological improvements, such as gene modification will enhance the yield and application of chitosan. This review focuses primarily on the numerous applications of chitosan in the biomedical field, including tissue engineering, wound dressing, drug delivery, and others.
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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
55
审稿时长
>12 weeks
期刊介绍: The International Journal of Polymer Science is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles on the chemistry and physics of macromolecules.
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