治疗乳腺癌的药用植物:综合综述

Q4 Veterinary
N. Alsubhi
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引用次数: 0

摘要

乳腺癌是女性的常见疾病。各种疗法,包括激素治疗、手术、放疗、化疗和靶向治疗,已可用于治疗现有的乳腺癌症。这些疗法可能会阻止癌症的发展和传播,尤其是在癌症处于早期阶段的情况下,但所有这些疗法都会对人类健康产生各种不利影响。癌症细胞比大多数正常细胞增殖更快,因此化疗是最合适的治疗方法。某些药物可以通过破坏细胞的控制中心区域来停止分裂细胞。其他药物可以抑制细胞分裂所必需的化学过程。相反,由于癌症通常在晚期被发现,治疗这种疾病是非常具有挑战性的。因此,建议避免这种致命的情况发生。多项研究表明,癌症与天然物质(如植物提取物、其组分和活性成分)之间存在持续的反向联系。这些生物活性植物化学物质在治疗癌症疾病中具有协同或累积效应。这篇综述文章研究了从不同植物来源获得的各种提取物/组分/活性成分对乳腺癌症疾病的影响。本研究提供了关于最常用植物的信息,包括高山Alpina galaga、桔梗Urtica dioica、番荔枝Annona muricata、迷迭香Rosmarinus officinalis、无花果Nigella sativa、锦鸡Murraya koenigii和桔梗。由于本研究中的信息,这些植物在临床前MCF-7癌症模型中表现出抗癌活性,通过减少细胞增殖、诱导程序性细胞死亡和触发细胞周期停滞。这篇综述所产生的信息将大大有助于发展科学界和医学界在开发癌症创新治疗方面的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The use of medicinal plants for combating breast cancer: A comprehensive review
Breast carcinoma is a common illness among females. Various therapies, including hormone therapy, surgery, radiotherapy, chemotherapy, and targeted treatment, have been available to treat existing breast cancer. These therapies can potentially halt the development and spread of cancer, especially if the disease is at an early stage, but all these treatments have various adverse effects on human health. Cancer cells proliferate more rapidly than most normal cells, so chemotherapy is the most suitable treatment. Certain medications can cease dividing cells by destroying the cell's control center region. Other drugs can inhibit the chemical processes essential for cell division. On the contrary, because cancer is frequently identified at a late phase, treating the disease is extraordinarily challenging. Therefore, it is advisable to avoid this fatal condition from occurring. Multiple studies have revealed a continuous inverse connection between cancer and natural materials, such as plant extracts, their fractions, and active principles. These bioactive phytochemicals' have synergistic or cumulative effects in the treatment of cancer disease. This review article examined the effect of various extracts/fractions/active principles obtained from diverse plant origins against breast cancer disease. Information regarding the most commonly used plants, including Alpina galaga, Urtica dioica, Annona muricata, Rosmarinus officinalis, Ficus carica, Nigella sativa, Murraya koenigii, and Urtica dioica have been presented in this study. Owing to the information in this study, these plants exhibited anticancer activities in preclinical MCF-7 carcinoma models by decreasing cell proliferation, inducing programmed cell death, and triggering cell-cycle arrest. The information generated from this review will significantly contribute to developing knowledge of the scientific and medical communities in developing innovative breast cancer treatments.
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来源期刊
Journal of Experimental Biology and Agricultural Sciences
Journal of Experimental Biology and Agricultural Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)
CiteScore
1.00
自引率
0.00%
发文量
127
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