我们对阿尔茨海默病（AD）中环状RNA（circRNA）的理解的最新进展；合成circRNA在AD临床治疗中的潜在应用

Frontiers in drug discovery Pub Date : 2022-08-24 DOI:10.3389/fddsv.2022.983030

Yuhai Zhao, V. Jaber, W. Lukiw

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引用次数: 5

摘要

信使核糖核酸介导的基因表达似乎在AD和中枢神经系统中具有重要意义，我们对circRNA的结构和组成的理解是，这些ssRNA在较长时间内具有高度的病理生理活性，并且在治疗上可以设计和合成携带多种ssRNA介导的调节信号。基于这些和其他最近的发现，本意见“论文将：1）阐述我们目前对circRNA在神经退行性变中的新作用的理解，特别是对AD的理解；和2）讨论将含有多个插入的miRNA、（AM；antagomir）、抗-mRNA和/或其他序列的合成circRNA与个性化的创新药物串联使用的有趣可能性

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Current advances in our understanding of circular RNA (circRNA) in Alzheimer’s disease (AD); the potential utilization of synthetic circRNAs as a therapeutic strategy in the clinical management of AD

mRNA-mediated gene expression appears to be signi cantly in AD and CNS, our understanding of con ﬁ guration and composition of circRNA is these ssRNAs are highly can in pathophysiological for extended periods, and therapeutically can be designed and synthesized to carry multiple ssRNA-mediated regulatory signals. Based on these and other very recent ﬁ ndings this Opinion ” paper will: 1) address our current understanding of the emerging role of circRNAs in neurodegeneration with special reference to AD; and 2) discuss the intriguing possibility of using synthetic circRNAs containing multiple inserted miRNA, (AM; antagomir), anti-mRNA and/or other sequences in tandem combination with a personalized as an innovative for the and

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Frontiers in drug discovery

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