植物化学物质在癌症预防中的作用:证据综述

N. M. Meybodi, A. Mortazavian, A. Monfared, S. Sohrabvandi, F. Meybodi
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引用次数: 60

摘要

背景:癌症通常被认为是一种肿瘤性疾病,具有特殊的病因和病因以及保护因素。尽管它仍然很难治疗,但它是可以预防的。最近,人们对饮食中植物化学物质的摄入对潜在的癌症化学预防的兴趣显著增加。证据获取:本报告根据PubMed、Science direct、Google Scholar和Scopus 1996年以后的出版物,使用癌症、化学预防和植物化学关键词,回顾了植物化学消费在癌症预防中的作用。结果:定期摄入植物化学物质已被证明可以在癌症的不同阶段(包括起始、促进和发展)预防癌症。考虑到动物模型,第二步是癌症化学预防的主要阶段。结论:参与化学预防的植物化学物质可分为酚类、类胡萝卜素类、生物碱类、有机硫化物类和含氮化合物类。它们能够通过不同的机制阻止、推迟和逆转致癌作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phytochemicals in Cancer Prevention: A Review of the Evidence
Context: Cancer generally is considered as a neoplastic disease with particular causative and etiologic factors as well as protective elements. Although it has remained difficult to treat, it is preventable. Recently, the interest in dietary phytochemicals intake has considerably increased for potential cancer chemoprevention. Evidence Acquisition: This report reviews the role of phytochemical consumption in cancer prevention based on publications from PubMed, Science direct, Google Scholar, and Scopus from the year 1996 onward using cancer, chemoprevention, phytochemical keywords. Results: Regular intake of phytochemicals has been demonstrated to prevent cancer during its different stages including initiation, promotion and progression. Considering the animal models, the second step is the main stage for cancer chemoprevention. Conclusions: The phytochemicals involved in chemoprevention can be categorized in different groups naming phenolics, carotenoid, alkaloids, organosulfur compounds and nitrogen-containing compounds. They are able to stop, postpone and reverse carcinogenesis by different mechanisms.
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