木麻黄提取物乳剂的光保护作用

IF 2.3 Q3 PHARMACOLOGY & PHARMACY
Juliana Andriolli Ribeiro, E. Magri, I. Gonçalves, K. Paese, J. Roman, A. T. Valduga
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引用次数: 0

摘要

叶巴木酯的成分中含有高浓度的酚类化合物。这类次级代谢产物在紫外线和可见光波长上表现出很强的摩尔吸收率值。本研究评估了叶叶提取物对防晒霜配方体外防晒系数(SPF)值的影响。制备的防晒霜配方以非离子乳液为基础,以椰油酯提取物和/或阿伏苯酮为活性剂。通过紫外-可见光谱法测定制剂的SPF和白藜芦醇保护作用。叶蜂提取物和阿伏苯酮对SPF有协同作用。5%的叶母叶提取物将5%的avobanzone配方的SPF从28.46±5.45提高到40.48±0.84。5%的叶母叶提取物避免了紫外线辐射对白藜芦醇的降解。在相同的浓度下,avobenzone对白藜芦醇的保护作用比yerba-mate提取物小。在12天的储存过程中,叶巴美酯+阿伏苯酮的配方的pH值变化较小。yerba-mate和阿伏苯酮制剂的铺展性分布与阿伏苯酮类制剂的分布相似。本文报道的结果显示了叶巴甲提取物在光保护制剂中的适用性,突出了其体外作用,并为探索这一特性的新研究开辟了可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photoprotector Effect of Emulsions with Yerba-Mate (Ilex paraguariensis) Extract
Yerba-mate contains in its composition a high concentration of phenolic compounds. This class of secondary metabolites exhibits strong values of molar absorptivity on ultraviolet and visible wavelengths. This study evaluated the effect of yerba-mate extracts on the in vitro solar protection factor (SPF) value of sunscreen formulations. The sunscreen formulations were prepared to have non-ionic lotion as a basis and yerba-mate extract and/or avobenzone as active agents. The SPF and resveratrol protective effect of the formulations were determined by UV-vis spectrometry. A synergic effect between the yerba-mate extract and avobenzone on the SPF was found. Yerba-mate extract at 5% improved the SPF of the avobenzone 5% formulation from 28.46 ± 5.45 to 40.48 ± 0.84. Yerba-mate extract at 5% avoided resveratrol degradation by ultraviolet radiation. At this same concentration, avobenzone produced a smaller effect than yerba-mate extracts in resveratrol protection. The formulations with yerba-mate + avobenzone presented smaller changes in pH values during 12 days of storage. The spreadability profile of yerba-mate and avobenzone formulations was similar to the profile of avobenzone formulations. The results reported here show the suitability of the yerba-mate extract use in photoprotective formulations, highlighting their in vitro effect and opening possibilities for new investigations exploring this property.
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来源期刊
Scientia Pharmaceutica
Scientia Pharmaceutica Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.60
自引率
4.00%
发文量
67
审稿时长
10 weeks
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