纳米材料抗SARS-CoV-2的应用:强调其对新出现的关注变体的有用性

IF 4.1 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Reema Iqbal, Sadia Khan, H. M. Ali, Maham Khan, Shahid Wahab, Tariq Khan
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引用次数: 0

摘要

研究人员现在正在寻找纳米材料来对抗导致爆发甚至大流行的严重传染病。在过去的两年里,SARS-CoV-2几乎给各行各业带来了混乱,并对所有可用的治疗方法提出了挑战。虽然很快就研制出了针对它的疫苗,但最紧迫的问题是由于病毒株的迅速演变而引起的令人关切的变种的出现。由这些变异引起的较高的致病性和较高的感染死亡率使现有疫苗的效力降低,生产进一步疫苗的努力是一项昂贵的努力。虽然正在研究几种技术,如免疫疗法和重新利用药物研究,以尽量减少病毒感染,但还必须考虑纳米技术的基本原理,以加强抗sars - cov -2的努力。例如,银纳米颗粒(AgNPs)已被有效应用于SARS-CoV-2。同样,纳米材料已经在口罩、手套和消毒剂中进行了测试,以帮助控制SARS-CoV-2。纳米技术也有助于诊断,如快速和准确的检测和治疗,如mRNA疫苗和其他抗病毒药物进入体内。由于聚合物纳米颗粒具有可调节的释放动力学、特异性和多模态药物组成,其发展被称为传统药物的一种选择策略。我们的文章探讨了纳米材料在管理关注的变体方面的潜力。这将通过强调纳米材料在以下方面对病毒起作用的固有能力来实现:抑制SARS-CoV-2的进入,抑制SARS-CoV-2中的RNA复制,并最终抑制其释放。在这篇综述中,对纳米材料在这些领域的潜力进行了详细的讨论,并将其与当前和未来新出现的关注变体相结合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Application of nanomaterials against SARS-CoV-2: An emphasis on their usefulness against emerging variants of concern
Researchers are now looking to nanomaterials to fight serious infectious diseases that cause outbreaks and even pandemics. SARS-CoV-2 brought chaos to almost every walk of life in the past 2 years and has challenged every available treatment method. Although vaccines were developed in no time against it, the most pressing issue was the emergence of variants of concern arising because of the rapidly evolving viral strains. The higher pathogenicity and, in turn, the higher mortality rate of infections caused by these variants renders the existing vaccines less effective and the effort to produce further vaccines a costly endeavor. While several techniques, such as immunotherapy and repurposed pharmaceutical research, are being studied to minimize viral infection, the fundamentals of nanotechnology must also be considered to enhance the anti-SARS-CoV-2 efforts. For instance, silver nanoparticles (AgNPs) have been applied against SARS-CoV-2 effectively. Similarly, nanomaterials have been tested in masks, gloves, and disinfectants to aid in controlling SARS-CoV-2. Nanotechnology has also contributed to diagnoses such as rapid and accurate detection and treatment such as the delivery of mRNA vaccines and other antiviral agents into the body. The development of polymeric nanoparticles has been dubbed a strategy of choice over traditional drugs because of their tunable release kinetics, specificity, and multimodal drug composition. Our article explores the potential of nanomaterials in managing the variants of concern. This will be achieved by highlighting the inherent ability of nanomaterials to act against the virus on fronts such as inhibition of SARS-CoV-2 entry, inhibition of RNA replication in SARS-CoV-2, and finally, inhibition of their release. In this review, a detailed discussion on the potential of nanomaterials in these areas will be tallied with their potential against the current and emerging future variants of concern.
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来源期刊
Frontiers in Nanotechnology
Frontiers in Nanotechnology Engineering-Electrical and Electronic Engineering
CiteScore
7.10
自引率
0.00%
发文量
96
审稿时长
13 weeks
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