Critical Analysis of Formulation andProbable Mode of Action of Avipattikara churna: A Comprehensive Review

Background: The mode of action of a compound Ayurvedic formulation is a critical and essential issue to be concentrated in assuring the therapeutic efficacy and safety based on its composition. Avipattikara Churna is one of the commonly used formulations containing herbs-mineral drugs. Objective: To emphasize the rationality of Avipattikara Churna and its mode of action by classical and contemporary review. Data Source: Classical texts like Vangasena Samhita, Bhaishajya Ratnavali, Rasendra Sara sangraha, Rasendra Chintamani, and published research works. Material and Methods: In the present study a critical analysis based on ingredients and probable mode of action of Avipattikara Churna in different indicated clinical conditions like agnimandya (digestive impairment), vibandha (constipation), amlapitta (hyperacidity), arsha (piles), mutraghata (retention of urine) and prameha (diabetes mellitus) were done based on classical and contemporary research works. Result: Data from the critical review of classical and contemporary research works. Conclusion: Avipattikara Churna is a versatile formulation used in a wide range of gastrointestinal disorders. By this review, it can be emphasized that Avipattikara Churna, which is in clinical practice for Amlapitta (Hyperacidity) and vibandha (constipation) is a tailored formula by its ingredients. In-vivo studies not only justify the effectiveness of the formulation but provide more evidence of the safety and efficacy of the formulation. Clinical research works substantiate its significant gastroprotective activity.