是否有可能影响COVID-19感染的发病和病程?(俄斯特拉发大学医院护士的一项研究结果)

Q4 Health Professions
J. Bystroň, Tomáš Balner, Jana Kačorová
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引用次数: 0

摘要

一项单中心试点研究评估了在捷克共和国第三波COVID-19大流行(delta型)期间,俄斯特拉发大学医院的51名护士使用Imunor预防COVID-19的效果。该研究的主要目的是确定在停药后1个月、2个月和1个月定期给药Imunor是否能预防在高风险环境中门诊和住院工作的护士感染SARS-CoV2。COVID-19患者该研究的次要目的是评估COVID-19患者的病程是否会更温和。还监测了研究对象因COVID-19住院的需要和研究准备的总体耐受性。在同一家医院工作的一组其他护士在研究期间接种了SARS-Cov2疫苗作为对照。在整个研究期间(治疗期间和治疗后1个月),只有2名护士出现了不需要住院的COVID-19轻度病程,患者仅在家中隔离2周,仅进行对症治疗。两周后,他们回到了全负荷工作状态。统计分析证实,在70%的研究天数中,预防效果具有显著的统计学意义(p≤0.00001)。在剩余30%的天数中(始终只有1名护士丧失工作能力),少数研究对象无法表达统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is it possible to influence the onset and course of COVID-19 infection? (Results of a study by nurses at the University Hospital Ostrava)
A pilot monocentric study evaluated the effect of Imunor on the prevention of COVID-19 in 51 nurses at the University Hospital Ostrava during the third wave of the COVID-19 pandemic (delta variant) in the Czech Republic. The primary objective of the study was to determine whether regular administration of Imunor for 1 month, 2 months, and 1 month after discontinuation prevented SARS-CoV2 infection in nurses working in outpatient and inpatient settings in high-risk environments. with patients with COVID-19. The secondary objective of the study was to evaluate whether the course of the disease would be milder in COVID-19. The need for hospitalization of study subjects for COVID-19 and the overall tolerability of the study preparation were also monitored. A set of other nurses working at the same hospital who were vaccinated against SARS-Cov2 during the study was used as a control. Throughout the study period (during treatment and 1 month after treatment), only 2 nurses experienced a mild course of COVID-19 disease that did not require hospitalization, patients were only isolated for 2 weeks at home with only symptomatic treatment. and after 2 weeks they returned to full workload. Statistical analysis confirmed a statistically highly significant preventive effect (p ≤ 0.00001) for 70% of the study days. In the remaining 30% of days (when there was always only 1 nurse on incapacity for work), it was not possible to express statistical significance for a small number of study subjects.
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来源期刊
Klinicka Farmakologie a Farmacie
Klinicka Farmakologie a Farmacie Health Professions-Pharmacy
CiteScore
0.30
自引率
0.00%
发文量
20
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