用一种常见酶的抑制剂对抗吸血昆虫、杂草和遗传性疾病

Q2 Agricultural and Biological Sciences

Outlooks on Pest Management Pub Date : 2022-04-01 DOI:10.1564/v33_apr_04

S. Duke, A. Chittiboyina

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引用次数: 0

摘要

在过去的40年里，两种非常相似的分子，除草剂美索三酮和药物尼替西酮，被发现可以杀死杂草，治疗遗传性疾病I型酪氨酸血症，并杀死吸血昆虫，按时间顺序排列。这两种化合物通过抑制植物、人类和昆虫体内的对羟基苯基丙酮酸双加氧酶(HPPD)，有效地完成了这些看似不同的任务。这是一个化学类的潜在用途的一个例子，通过一个共同的酶来连接广泛的生物用途。

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Battling Blood-Feeding Insects, Weeds, and Hereditary Diseases with Inhibitors of a Common Enzyme

Over the past 40 years, two very similar molecules, the herbicide mesotrione and the pharmaceutical nitisinone, have been found to kill weeds, treat the hereditary disease type I tyrosinemia, and kill blood-feeding insects, chronologically in that order. These two compounds effectively accomplish these seemingly diverse tasks by inhibiting the same enzyme, p-hydroxyphenylpyruvate dioxygenase (HPPD), in plants, humans, and insects. This is an example of the potential use of a chemical class for a wide range of biological uses linked by a common enzyme.

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来源期刊

Outlooks on Pest Management Agricultural and Biological Sciences-Insect Science

自引率

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发文量

期刊介绍： Research and development in the crop protection and crop enhancement sector continues to grow at pace. Those associated with the agriculture and food industries, researchers in academia, government organisations, legislators, and professionals involved with the development and environmental impact of pesticides and biotechnology can all benefit from Outlooks on Pest Management. This bi-monthly journal provides a unique blend of international news and reviews covering all aspects of the management of weeds, pests and diseases through chemistry, biology and biotechnology.