Polymicrobial interaction in biofilm: mechanistic Insights.

Polymicrobial biofilm formation during multi-species infection is a serious threat growing worldwide. According to CDC, the microbial biofilm infection covers more than 65% of total infection. In many diseases, their natural habitat does not have one causative agent because most of the species exist in co-aggregation (such as CF, OM, Dental Caries) leading to polymicrobial biofilm. Polymicrobial biofilm is a big problem in bacterio-fungal and inter-species bacterial diseases developed during chronic illness and created a major health burden globally. This review focused on various aspects of polymicrobial biofilms such as why they are forming polymicrobial biofilm arrangements, the significance of studying these biofilms, the interaction between causative microbes. Also, we reviewed how these interactions and polymicrobial formations make the biofilm more recalcitrant towards the treatment. Understanding the mechanistic process behind these biofilm formations gives an insight into specific molecules, proteins responsible for their polymicrobial nature are likely to be very helpful in anti-microbial researches.