多胺途径与雄激素受体配体对肌肉合成代谢的影响有关

JCSM rapid communications Pub Date : 2020-11-19 DOI:10.1002/rco2.28

M. Kanou, Katsuyuki Nakamura, Kyohei Horie, H. Sakai, Yuta Yanagihara, Iori Sakakibara, K. Yamana, Yuuki Imai

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引用次数: 2

摘要

肌肉萎缩是伴随衰老的常见疾病。雄激素显著增加骨骼肌质量，但雄激素受体（AR）在骨骼肌中的作用尚不明确。TEI‐SARM2是一种新型选择性雄激素受体调节剂（SARM），被开发为治疗肌肉萎缩性疾病的候选药物。

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Polyamine pathway is associated with muscle anabolic effects by androgen receptor ligand

Muscle wasting is a common condition concomitant with aging. Androgens significantly increase skeletal muscle mass, but the role of the androgen receptor (AR) in skeletal muscle is not well established. TEI‐SARM2, a novel selective androgen receptor modulator (SARM), was developed as a pharmaceutical candidate for the treatment of muscle wasting diseases.

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JCSM rapid communications

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审稿时长

10 weeks