儿童癌症、创伤后应激和恐惧相关神经回路

International Journal of Hematologic Oncology Pub Date : 2019-07-11 DOI:10.2217/ijh-2019-0002

H. Marusak, F. Harper, J. Taub, C. Rabinak

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引用次数: 9

摘要

本文综述了儿童癌症相关创伤后应激症状(PTSS)的神经生物学效应。我们首先考虑关于儿童癌症相关ptsd患病率和预测因素的研究，并将这些研究与典型发展(即非癌症)人群的研究进行比较。然后，我们简要介绍了与PTSS有关的大脑区域，并回顾了非癌症人群中PTSS神经相关的神经影像学研究。接下来，我们提出了未来研究的框架和建议。特别是，需要同时评估PTSS和神经影像学，以及社会人口统计学、医学、家庭因素和其他生活事件，以揭示导致癌症相关PTSS的机制。我们回顾了儿童癌症的神经影像学研究结果，以及最近一项关于癌症相关PTSS的研究，作为这一研究的起点。

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Pediatric cancer, posttraumatic stress and fear-related neural circuitry

This review examines the neurobiological effects of pediatric cancer-related posttraumatic stress symptoms (PTSS). We first consider studies on prevalence and predictors of childhood cancer-related PTSS and compare these studies to those in typically developing (i.e., noncancer) populations. Then, we briefly introduce the brain regions implicated in PTSS and review neuroimaging studies examining the neural correlates of PTSS in noncancer populations. Next, we present a framework and recommendations for future research. In particular, concurrent evaluation of PTSS and neuroimaging, as well as sociodemographic, medical, family factors, and other life events, are needed to uncover mechanisms leading to cancer-related PTSS. We review findings from neuroimaging studies on childhood cancer and one recent study on cancer-related PTSS as a starting point in this line of research.

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来源期刊

International Journal of Hematologic Oncology

自引率

0.00%

发文量

审稿时长

13 weeks

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