免疫接种炎症反应机制及其对免疫原性的影响

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-09-30 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.09.011

Chunlan Zhuang, Ying-Ying Su, Ting Wu

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引用次数: 0

摘要

疫苗接种是人类最伟大的发明之一，每年可预防数百万人感染传染病和死亡。随着免疫覆盖率的不断提高，疫苗的安全性受到广泛关注。接种疫苗常见的不良反应主要由炎症引起，但免疫后的免疫反应和生物损伤非常复杂，可能的机制尚未完全揭示。探讨疫苗接种后炎症与免疫原性的关系，对疫苗上市后的监测和管理具有重要意义。本文综述了疫苗接种后炎症反应的机制及其对免疫原性的潜在影响。关键词：疫苗不良反应；炎症；免疫原性；上市后监督

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Mechanism of inflammatory reaction to vaccination and its effects on immunogenicity

Vaccination, one of the greatest inventions of mankind, prevents millions of people from infectious diseases and death each year. With the continuous improvement in immunization coverage, the safety of vaccines has attracted widespread attention. Common adverse reactions to vaccinations are mainly caused by inflammation, but the immune responses and biological damages following immunization are so complicated that the possible mechanisms have not been completely unveiled. Exploring the relationship between inflammation and immunogenicity after vaccination is of great significance for the monitoring and management of vaccines after marketing. This article reviewed the mechanism of inflammatory responses after vaccination and its potential impact on immunogenicity. Key words: Vaccine adverse reaction; Inflammation; Immunogenicity; Post-marketing surveillance

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.