异位脂肪库:生理作用及其对心血管疾病连续体的影响

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
A. Bragina, A. Tarzimanova, K. Osadchiy, Yu. N. Rodionova, M. G. Kudryavtseva, Z. Jafarova, D. Bayutina, V. Podzolkov
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引用次数: 2

摘要

肥胖是一种非传染性流行病。脂肪组织的内脏分布是心血管疾病及其并发症发生的重要因素。除了网膜和皮下组织中的内脏腹部脂肪库外,还有其他异位脂肪组织库:心外膜脂肪组织(EAT)、血管周围脂肪组织(PVAT)和肾周脂肪组织。本文综述了PVAT和EAT在健康和病理条件下的生理作用和分子基础;脂肪因子和细胞因子的相互作用,它们对心血管疾病的发展和进展的贡献。这篇综述讨论了这一领域中众所周知的事实和有争议的问题。对肥胖人群血管和心肌病理机制的全面研究,以及对心血管并发症早期预测的生物标志物的识别,将有助于制定有针对性的预防措施和选择治疗策略,这与当代个性化医疗的理念是一致的。我们分析了2001-2020年图书馆和PubMed科学图书馆的国内外文献来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ectopic Fat Depots: Physiological Role And Impact On Cardiovascular Disease Continuum
Obesity is a non-infectious pandemic. The visceral distribution of adipose tissue is a significant factor in the development of cardiovascular diseases and their complications. Along with the visceral abdominal depot in omentum and subcutaneous tissue, there are other ectopic adipose tissue depots: epicardial adipose tissue (EAT), perivascular adipose tissue (PVAT) and perirenal adipose tissue. This article presents a review of the physiological role and molecular basis of the PVAT and EAT function in healthy, as well as in pathological, conditions; the interaction of adipokines and cytokines, their contribution to the development and progression of cardiovascular diseases. The review discusses well-known facts and controversial issues in this field. Comprehensive investigation of the mechanisms of vascular and myocardial pathology in obese people, along with identification of biomarkers for early prediction of cardiovascular complications, would contribute to the development of targeted preventive measures and choice of therapeutic strategies, which is consistent with the contemporary concept of personalized medicine. We have analyzed domestic and foreign literature sources in eLIBRARY and PubMed scientific libraries for the period of 2001-2020.
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来源期刊
Russian Open Medical Journal
Russian Open Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.90
自引率
0.00%
发文量
39
期刊介绍: Russian Open Medical Journal (RusOMJ) (ISSN 2304-3415) is an international peer reviewed open access e-journal. The website is updated quarterly with the RusOMJ’s latest original research, clinical studies, case reports, reviews, news, and comment articles. This Journal devoted to all field of medicine. All the RusOMJ’s articles are published in full on www.romj.org with open access and no limits on word counts. Our mission is to lead the debate on health and to engage, inform, and stimulate doctors, researchers, and other health professionals in ways that will improve outcomes for patients. The RusOMJ team is based mainly in Saratov (Russia), although we also have editors elsewhere in Russian and in other countries.
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