乳腺癌DNA甲基化和羟甲基化研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-02-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.02.014

Qingtao Ni, Chi Pan

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引用次数: 0

摘要

乳腺癌是妇女中最常见的恶性肿瘤之一，也是女性癌症患者死亡的第二大原因。近年来，中国乳腺癌的发病率逐年上升，乳腺癌患者的年龄也越来越年轻化。乳腺癌的发病机制复杂，与年龄、家族史、遗传变异等因素有关。随着表观遗传学的发展，DNA修饰在乳腺癌的发生发展中起着重要的作用。本文综述了DNA甲基化和羟甲基化在乳腺癌中的研究进展。关键词:乳腺肿瘤;DNA甲基化;Hydroxymethylation;分子生物学

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Progress of DNA methylation and hydroxymethylation in breast cancer

Breast cancer is one of the most common malignant tumors in women and the second leading cause of death in female cancer patients. In recent years, the incidence of breast cancer has been increasing in China year by year, and the age of breast cancer patients becomes younger and younger. The pathogenesis of breast cancer is complex and related to many factors, such as age, family history and genetic variation. With the development of epigenetics, DNA modification plays an important role in the occurrence and development of breast cancer. This article reviews the research of DNA methylation and hydroxymethylation in breast cancer. Key words: Breast neoplasms; DNA methylation; Hydroxymethylation; Molecular biology

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.