2-氯苯甲酰硫脲修饰MCM-41给药

Q3 Chemistry
F. Emen, R. E. Demirdöğen, G. Avsar, D. Kiliç
{"title":"2-氯苯甲酰硫脲修饰MCM-41给药","authors":"F. Emen, R. E. Demirdöğen, G. Avsar, D. Kiliç","doi":"10.18596/JOTCSA.467177","DOIUrl":null,"url":null,"abstract":"Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO 2 ) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO 2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m 2 /g 2-chloro-benzoythiourea modified MCM-4, respectively . The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery\",\"authors\":\"F. Emen, R. E. Demirdöğen, G. Avsar, D. Kiliç\",\"doi\":\"10.18596/JOTCSA.467177\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO 2 ) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO 2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m 2 /g 2-chloro-benzoythiourea modified MCM-4, respectively . The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.\",\"PeriodicalId\":17402,\"journal\":{\"name\":\"Journal of the Turkish Chemical Society, Section A: Chemistry\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Turkish Chemical Society, Section A: Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18596/JOTCSA.467177\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Turkish Chemical Society, Section A: Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18596/JOTCSA.467177","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 2

摘要

制备了介孔2-氯苯甲酰硫脲修饰的MCM-41,并在超临界二氧化碳(sC-CO 2)环境中负载布洛芬。制备了2-氯苯并甲硫脲改性MCM-41,并通过XRD、FT-IR、SEM和BET等技术对其进行了表征。低角XRD(100)和(110)反射为介孔sio2结构。在250 ~ 305 nm范围内观察了非均匀球的粒径。MCM-41的BET表面积为1506 m2 /g, 2-氯-苯并噻吩脲改性MCM-4的BET表面积为306 m2 /g。对布洛芬在模拟体液中的吸收和释放进行了研究。结果表明,2-氯-苯并噻吩脲修饰的MCM-41对药物具有较高的吸附能力,且药物释放速度较慢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery
Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO 2 ) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO 2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m 2 /g 2-chloro-benzoythiourea modified MCM-4, respectively . The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.60
自引率
0.00%
发文量
81
审稿时长
5 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信