{"title":"机器般的老化修复。解开SENS议程的关键假设","authors":"Pablo García-Barranquero, M. Bertolaso","doi":"10.1387/theoria.23544","DOIUrl":null,"url":null,"abstract":"The possibility of curing aging is currently generating hopes and concerns among entrepreneurs, experts, and the general public. This article aims to clarify some of the key assumptions of the Strategies for Engineered Negligible Senescence agenda, one of the most prominent paradigms for rejuvenation. To do this, we present the three fundamental claims of this research program: (1) aging can be repaired; (2) rejuvenation is possible through the reversal of all molecular damage; (3) and the human organism is a sophisticated machine. Secondly, we argue that this agenda fits with a machine conception of the organism (described by Daniel Nicholson); we show that, if aging is understood from this philosophical approach, there is an internal confusion in the research program between what is repair and what is rejuvenation. Finally, we state that this theoretical viewpoint connects with scientific criticism and reinforces the idea that there are limits to the aspirations to live indefinitely young.","PeriodicalId":43859,"journal":{"name":"Theoria-A Swedish Journal of Philosophy","volume":null,"pages":null},"PeriodicalIF":0.3000,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda\",\"authors\":\"Pablo García-Barranquero, M. Bertolaso\",\"doi\":\"10.1387/theoria.23544\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The possibility of curing aging is currently generating hopes and concerns among entrepreneurs, experts, and the general public. This article aims to clarify some of the key assumptions of the Strategies for Engineered Negligible Senescence agenda, one of the most prominent paradigms for rejuvenation. To do this, we present the three fundamental claims of this research program: (1) aging can be repaired; (2) rejuvenation is possible through the reversal of all molecular damage; (3) and the human organism is a sophisticated machine. Secondly, we argue that this agenda fits with a machine conception of the organism (described by Daniel Nicholson); we show that, if aging is understood from this philosophical approach, there is an internal confusion in the research program between what is repair and what is rejuvenation. Finally, we state that this theoretical viewpoint connects with scientific criticism and reinforces the idea that there are limits to the aspirations to live indefinitely young.\",\"PeriodicalId\":43859,\"journal\":{\"name\":\"Theoria-A Swedish Journal of Philosophy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2022-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Theoria-A Swedish Journal of Philosophy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1387/theoria.23544\",\"RegionNum\":3,\"RegionCategory\":\"哲学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"0\",\"JCRName\":\"PHILOSOPHY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Theoria-A Swedish Journal of Philosophy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1387/theoria.23544","RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"0","JCRName":"PHILOSOPHY","Score":null,"Total":0}
The machine-like repair of aging. Disentangling the key assumptions of the SENS agenda
The possibility of curing aging is currently generating hopes and concerns among entrepreneurs, experts, and the general public. This article aims to clarify some of the key assumptions of the Strategies for Engineered Negligible Senescence agenda, one of the most prominent paradigms for rejuvenation. To do this, we present the three fundamental claims of this research program: (1) aging can be repaired; (2) rejuvenation is possible through the reversal of all molecular damage; (3) and the human organism is a sophisticated machine. Secondly, we argue that this agenda fits with a machine conception of the organism (described by Daniel Nicholson); we show that, if aging is understood from this philosophical approach, there is an internal confusion in the research program between what is repair and what is rejuvenation. Finally, we state that this theoretical viewpoint connects with scientific criticism and reinforces the idea that there are limits to the aspirations to live indefinitely young.
期刊介绍:
Since its foundation in 1935, Theoria publishes research in all areas of philosophy. Theoria is committed to precision and clarity in philosophical discussions, and encourages cooperation between philosophy and other disciplines. The journal is not affiliated with any particular school or faction. Instead, it promotes dialogues between different philosophical viewpoints. Theoria is peer-reviewed. It publishes articles, reviews, and shorter notes and discussions. Short discussion notes on recent articles in Theoria are welcome.