圆锥蛇毒肽的抗糖尿病和抗癌活性研究进展

Pub Date : 2021-11-02 DOI:10.1080/22311866.2021.1944316
Varun Dhiman, D. Pant, T. Dhewa, Anita Padam
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引用次数: 0

摘要

摘要:本文介绍了许多康多肽作为抗糖尿病和抗癌药物的药理潜力。不同的作用机制,药理学及其肽化学也进行了讨论。本研究采用全面、透明的审查方法,对现有科学文献进行分析,重点是医学应用。它包括使用谷歌Scholar、PubMed、Research Gate和ISI web of knowledge等数据库对可用文献进行探索。相关数据和信息收集自不同的数据来源,包括科学数据库、对以前和最近发表的研究的同行评审以及综述文章。目前对不同康诺多肽可能的抗糖尿病和抗癌作用的研究比较有限,综述也比较全面。由此可见,康多肽在糖尿病和癌症治疗新一代药物的开发中具有重要的应用价值,为从海洋生态系统中开发药物提供了进一步的可能性。
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A Review on the Antidiabetic and Anticancer Activities of Conus Venom Peptides
Abstract This article presents the pharmacological potential of numerous conopeptides as antidiabetic and anticancer agents. Different mechanisms, pharmacology with their peptide chemistry are also discussed. The study uses a comprehensive, transparent review approach with the analysis of available scientific literature focusing the medicinal applications. It involves the exploration of available literature using databases like Google Scholar, PubMed, Research Gate, and ISI web of knowledge. The relevant data and information were collected from different data sources including scientific databases, peer-review of previous and recently published research, and review articles. It has been found that limited research and comprehensive reviews have focused on investigating the possible antidiabetic and anticancer potential of different conopeptides. It is concluded that conopeptides are highly potent in the development of new generation medicines for diabetes and cancer cure which provide further possibilities in exploring drugs from the marine ecosystem.
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