沙丁胺醇联合布地奈德治疗小儿支气管哮喘及其对嗜酸性粒细胞的影响。

IF 2.6 4区医学 Q2 Medicine

Minerva pediatrica Pub Date : 2020-09-22 DOI:10.23736/S0026-4946.20.06003-X

Suihua Li, Qing-xiu Mei, D. Qian, Xianghong Huang, C. Fan, J. Quan

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引用次数: 0

摘要

背景探讨沙丁胺醇联合布地奈德治疗小儿支气管哮喘（BA）及其对嗜酸性粒细胞（EOS）的影响。方法收集2016年7月至2017年6月在我院住院治疗的BA患儿98例，按随机数表分为对照组（n=49）和观察组（n=49%）。对照组用布地奈德治疗，观察组用沙丁胺醇联合布地奈德。比较两组治疗后的临床疗效、肺功能和免疫系统中T淋巴细胞亚群[包括分化簇3（CD3）+、CD4+、CD8+和CD4+/CD8+]水平；比较治疗前和治疗后1、4和8周儿童嗜酸性粒细胞阳离子蛋白（ECP）和嗜酸性粒素水平；比较治疗前后儿童血液和诱导痰中EOS计数的变化，并比较治疗后1、4和8周EOS凋亡率。结果观察组治疗有效率明显高于对照组（p＜0.05），治疗后肺功能指标明显优于对照组（p＜0.05），治疗后两组儿童ECP和eotaxin水平均较治疗前下降，观察组优于对照组（p<0.05），观察组下降幅度明显大于对照组。治疗后1、4、8周，观察组EOS凋亡率明显高于对照组（p<0.05）。结论沙丁胺醇联合布地奈德治疗小儿BA疗效显著；它能迅速恢复肺功能，提高肺部免疫力，降低儿童eotaxin、ECP和EOS水平，促进EOS凋亡。

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Salbutamol combined with budesonide in treatment of pediatric bronchial asthma and its effect on eosinophils.

BACKGROUND To investigate and discuss the salbutamol combined with budesonide in treatment of pediatric bronchial asthma (BA) and its effect on eosinophils (EOS). METHODS 98 BA children admitted and treated in our hospital from July 2016 to June 2017 were collected and divided into control group (n=49) and observation group (n=49) according to random number table. The children in control group were treated with budesonide and those in observation group were treated with salbutamol combined with budesonide. The clinical efficacy, pulmonary functions and levels of T-lymphocyte subsets [including cluster of differentiation 3 (CD3)+, CD4+, CD8+ and CD4+/CD8+] in the immune system between two groups were compared after the treatment; the levels of eosinophil cationic protein (ECP) and eotaxin in the children were compared before the treatment and at 1, 4 and 8 weeks after the treatment; the changes in EOS counts in blood and induced sputum of the children before and after the treatment were compared, and the EOS apoptosis rate was compared at 1, 4 and 8 weeks after the treatment. RESULTS The effective rate of treatment in observation group was significantly higher than that in control group (p<0.05). After the treatment, the indexes of pulmonary function in observation group were obviously better than those in control group (p<0.05). Compared with those in control group, the levels of CD3+, CD4+ and CD4+/CD8+ of the children in observation group were elevated remarkably, while the CD8+ level was lowered (p<0.05). The levels of ECP and eotaxin in the two groups were decreased after the treatment compared with those before the treatment, and the levels in observation group were superior to those in control group (p<0.05). After the treatment, the EOS counts of the both groups of children were lower than those before the treatment, and the decrease in observation group was more notable than that in control group. At 1, 4 and 8 weeks after the treatment, the EOS apoptosis rate in observation group was obviously higher than that in control group (p<0.05). CONCLUSIONS The treatment of salbutamol combined with budesonide for pediatric BA has significant therapeutic effects; it can restore the pulmonary functions rapidly and improve the immunity of the lung, reduce the levels of eotaxin, ECP and EOS of the child patients and promote EOS apoptosis.

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来源期刊

Minerva pediatrica PEDIATRICS-

CiteScore

2.70

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： Minerva Pediatrica publishes scientific papers on pediatrics, neonatology, adolescent medicine, child and adolescent psychiatry and pediatric surgery. Manuscripts may be submitted in the form of editorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.