前列腺癌骨转移后骨破坏相关信号通路的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-01-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2020.01.014

Zhengqin Geng, Ling Zhou, Jiadai Tang

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引用次数: 0

摘要

骨转移是晚期前列腺癌患者常见的并发症之一。骨转移引起的骨相关事件(SRE)如疼痛等治疗效果不佳，预后差，严重影响患者的生活质量。因此，探讨前列腺癌的骨转移具有重要意义。目前骨转移的相关机制尚不清楚，宿主微环境与前列腺癌细胞相互作用形成的恶性循环可能是重要原因，其中RANK-RANKL信号通路的研究相对成熟。本文综述了前列腺癌骨转移相关信号通路的研究现状，并阐述了相同信号分子在不同信号通路中的调控关系。关键词:前列腺肿瘤;骨转移;信号通路

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Progress of signaling pathways related to bone destruction after bone metastasis in prostate cancer

Bone metastasis is one of the common complications of patients with advanced prostate cancer. The treatment of skeletal-related events (SRE) caused by bone metastasis, such as the pain, is not effective, and the prognosis is poor, which seriously affects the quality of life of patients. Therefore, exploring the bone metastasis of prostate cancer is of great significance. At present, the relevant mechanism of bone metastasis is still unclear, and the vicious cycle formed by the interaction between the host microenvironment and prostate cancer cells, might be an important reason, among which, the research on RANK-RANKL signaling pathway is relatively mature. This article reviews the current research status of prostate cancer bone metastasis-related signaling pathways, and describes the regulatory relationships of the same signaling molecules in different signaling pathways. Key words: Prostate neoplasms; Bone metastasis; Signaling pathway

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.