Progress of signaling pathways related to bone destruction after bone metastasis in prostate cancer

Bone metastasis is one of the common complications of patients with advanced prostate cancer. The treatment of skeletal-related events (SRE) caused by bone metastasis, such as the pain, is not effective, and the prognosis is poor, which seriously affects the quality of life of patients. Therefore, exploring the bone metastasis of prostate cancer is of great significance. At present, the relevant mechanism of bone metastasis is still unclear, and the vicious cycle formed by the interaction between the host microenvironment and prostate cancer cells, might be an important reason, among which, the research on RANK-RANKL signaling pathway is relatively mature. This article reviews the current research status of prostate cancer bone metastasis-related signaling pathways, and describes the regulatory relationships of the same signaling molecules in different signaling pathways. Key words: Prostate neoplasms; Bone metastasis; Signaling pathway