GRIN2A突变和Landau-Kleffner综合征中的语言缺陷作为神经节律障碍

IF 1.2 3区心理学 Q2 LINGUISTICS

Journal of Neurolinguistics Pub Date : 2023-08-01 DOI:10.1016/j.jneuroling.2023.101139

Antonio Benítez-Burraco , Koji Hoshi , Elliot Murphy

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引用次数: 2

摘要

我们回顾了与GRIN2A突变相关的癫痫性失语症，重点是获得性儿童癫痫性失语症，如Landau-Kleffner综合征(LKS)。LKS儿童的自发言语表现为句法简化的话语，严重的词汇寻找困难和严重的语音错乱。将LKS描述为一种神经节律障碍，我们回顾了脑电图异常在非快速眼动(NREM)睡眠期间的典型表现，因为电癫痫持续状态与部分由GRIN2A突变引起的睡眠障碍有关。在朗道(Landau &;Kleffner, 1957，我们探索了神经过程，如尖波涟漪，睡眠纺锤波，慢振荡，以及它们的交叉频率耦合是如何对LKS中受干扰的语言相关过程所必需的，这在一定程度上解释了癫痫性失语症的语言特征。

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Language deficits in GRIN2A mutations and Landau–Kleffner syndrome as neural dysrhythmias

We review epilepsy-related aphasias in connection with GRIN2A mutations, focusing on acquired childhood epileptic aphasias such as Landau-Kleffner syndrome (LKS). The spontaneous speech of children with LKS exhibits syntactically simplified utterances, severe word finding difficulties, and severe phonological paraphasias. Characterizing LKS as a neural dysrhythmia, we review how EEG abnormalities typically manifested during non-rapid eye movement (NREM) sleep as electrical status epilepticus are related to sleeping disorders partly caused by GRIN2A mutations. Expanding on speculations originally put forward by Landau & Kleffner, 1957, we explore how neural processes such as sharp-wave ripples, sleep spindles, slow oscillations, and their cross-frequency couplings are necessary for language-related processes which are perturbed in LKS, accounting in part for the linguistic profile of epileptic aphasias.

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来源期刊

Journal of Neurolinguistics 医学-神经科学

CiteScore

3.90

自引率

5.00%

发文量

审稿时长

17.2 weeks

期刊介绍： The Journal of Neurolinguistics is an international forum for the integration of the neurosciences and language sciences. JNL provides for rapid publication of novel, peer-reviewed research into the interaction between language, communication and brain processes. The focus is on rigorous studies of an empirical or theoretical nature and which make an original contribution to our knowledge about the involvement of the nervous system in communication and its breakdowns. Contributions from neurology, communication disorders, linguistics, neuropsychology and cognitive science in general are welcome. Published articles will typically address issues relating some aspect of language or speech function to its neurological substrates with clear theoretical import. Interdisciplinary work on any aspect of the biological foundations of language and its disorders resulting from brain damage is encouraged. Studies of normal subjects, with clear reference to brain functions, are appropriate. Group-studies on well defined samples and case studies with well documented lesion or nervous system dysfunction are acceptable. The journal is open to empirical reports and review articles. Special issues on aspects of the relation between language and the structure and function of the nervous system are also welcome.