{"title":"水通道蛋白- 4ig在视神经脊髓炎中的免疫病理作用","authors":"K. Chan, Cl Ng, L. Yick","doi":"10.15406/moji.2017.05.00168","DOIUrl":null,"url":null,"abstract":"Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders. Recently, autoimmunity against aquaporin-4 (AQP4) water channel is identified to be the underlying immunopathogenetic mechanism of the majority of NMOSD patients. This is evidenced by the detection of IgG autoantibodies against aquaporin-4 (AQP4-IgG) in the serum of ~75%-80% of typical neuromyelitis optica patients. Detection of AQP4-IgG is highly specific for NMOSD, facilitates diagnosis of NMOSD and their distinction from classical multiple sclerosis. Besides its diagnostic value, AQP4-IgG is likely directly pathogenic in NMOSD. This review focuses on the immunopathological effects of AQP4-IgG in NMOSD.","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunopathological Effects Of Aquaporin-4 Ig G In Neuromyelitis Optica Spectrum Disorders\",\"authors\":\"K. Chan, Cl Ng, L. Yick\",\"doi\":\"10.15406/moji.2017.05.00168\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders. Recently, autoimmunity against aquaporin-4 (AQP4) water channel is identified to be the underlying immunopathogenetic mechanism of the majority of NMOSD patients. This is evidenced by the detection of IgG autoantibodies against aquaporin-4 (AQP4-IgG) in the serum of ~75%-80% of typical neuromyelitis optica patients. Detection of AQP4-IgG is highly specific for NMOSD, facilitates diagnosis of NMOSD and their distinction from classical multiple sclerosis. Besides its diagnostic value, AQP4-IgG is likely directly pathogenic in NMOSD. This review focuses on the immunopathological effects of AQP4-IgG in NMOSD.\",\"PeriodicalId\":90928,\"journal\":{\"name\":\"MOJ immunology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"MOJ immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/moji.2017.05.00168\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"MOJ immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/moji.2017.05.00168","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Immunopathological Effects Of Aquaporin-4 Ig G In Neuromyelitis Optica Spectrum Disorders
Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders. Recently, autoimmunity against aquaporin-4 (AQP4) water channel is identified to be the underlying immunopathogenetic mechanism of the majority of NMOSD patients. This is evidenced by the detection of IgG autoantibodies against aquaporin-4 (AQP4-IgG) in the serum of ~75%-80% of typical neuromyelitis optica patients. Detection of AQP4-IgG is highly specific for NMOSD, facilitates diagnosis of NMOSD and their distinction from classical multiple sclerosis. Besides its diagnostic value, AQP4-IgG is likely directly pathogenic in NMOSD. This review focuses on the immunopathological effects of AQP4-IgG in NMOSD.
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