费城阳性淋巴母细胞淋巴瘤：一例报告并文献复习。

Q1 Biochemistry, Genetics and Molecular Biology

Stem cell investigation Pub Date : 2019-09-07 DOI:10.21037/SCI.2019.06.06

M. Dragani, G. Andreani, C. Fava, F. Daraio, E. Gottardi, E. Giugliano, P. Nicoli, G. Rege‐Cambrin

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引用次数: 5

摘要

目前，费城阳性急性淋巴母细胞白血病已被广泛报道，但对费城阳性淋巴母细胞淋巴瘤(LBL)却知之甚少。文献记载仅有2例，均在治疗过程中死亡，而本中心治疗的患者在初诊3年后仍存活。采用无化疗方案，以达沙替尼加类固醇诱导，局部放疗肿块，然后进行骨髓移植。费城阳性淋巴母细胞淋巴瘤是一种难以诊断的疾病，这种极其罕见的疾病的治疗非常具有挑战性。

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Philadelphia-positive lymphoblastic lymphoma: a case report and review of the literature.

Philadelphia positive acute lymphoblastic leukemia is well documented nowadays but very little is known about Philadelphia positive lymphoblastic lymphoma (LBL). Only two cases are available in literature and both of them died during treatment whereas the patient treated in our center is still alive 3 years after the initial diagnosis. A chemo-free regimen was used in induction with dasatinib plus steroids with local radiotherapy on the mass, and then the patient underwent bone marrow transplant. Philadelphia positive lymphoblastic lymphoma is a difficult diagnosis to make and the management of this extremely rare disease is very challenging.

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来源期刊

Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

5.80

自引率

0.00%

发文量

期刊介绍： The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.