菊芋块茎提取物的生物学功能和特性

IF 0.8 4区农林科学 Q4 FOOD SCIENCE & TECHNOLOGY

Acta Alimentaria Pub Date : 2023-02-22 DOI:10.1556/066.2022.00118

N. A. Afoakwah, Y. Zhao, Y. Dong

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引用次数: 1

摘要

研究了菊芋块茎提取物(JAE)的生物活性，包括抗癌、抗菌和抑制消化的特性。结果表明，提取物能够以剂量依赖的形式抑制HT-29结肠癌细胞系(HT-29 cc细胞系)的癌症生长。在250 μg mL−1的剂量下，细胞增殖抑制率约为78.05±3.9%。Annexin V检测显示剂量依赖性DNA断裂，并检测到ht - 29cc细胞系的晚期凋亡诱导。根据浓度的不同，提取物能够在G1期停止HT-29 cc细胞系的细胞周期。此外，JAE阻止ht - 29cc细胞系生长，导致程序性细胞死亡。此外，其提取物还具有抑制脂肪酶和α-淀粉酶的作用。

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Biological functionality and characteristics of Jerusalem artichoke (Helianthus tuberosus L.) tuber extracts

Jerusalem artichoke tuber extracts (JAE) bioactivity including anticancer, antimicrobial, and digestion-inhibiting properties were investigated. The findings showed that the extracts were able to inhibit cancer growth in the HT-29 colon cancer cell line (HT-29 cc cell line) in a dose-dependent form. The suppression of cell proliferation rose to about 78.05 ± 3.9 percent at a dose of 250 μg mL−1. The Annexin V assay showed dose-dependent DNA fragmentation and detected late apoptotic induction in the HT-29 cc cell line. Depending on the concentration, the extract was able to stop the cell cycle in the HT-29 cc cell line at the G1 phase. Also, JAE prevented the HT-29 cc cell line growth, which resulted in programmed cell death. Additionally, the extracts are potential antibacterial agents and may inhibit lipase and α-amylase.

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来源期刊

Acta Alimentaria 农林科学-食品科技

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

18-36 weeks

期刊介绍： Acta Alimentaria publishes original papers and reviews on food science (physics, physical chemistry, chemistry, analysis, biology, microbiology, enzymology, engineering, instrumentation, automation and economics of foods, food production and food technology, food quality, post-harvest treatments, food safety and nutrition).