Advantages and disadvantages of menopause hormone therapy

With the extension of life expectancy and increased attention to quality of life, females pay more attention to physical and mental health problems, such as a variety of menopause-related symptoms, tissue atrophic degradation and metabolic dysfunction brought by ovarian hypofunction. Menopause hormone therapy(MHT) is the most effective method to alleviate the symptoms associated with ovarian dysfunction, and it can also prevent the occurrence of age-related chronic diseases in the early menopause stage. Some clinical studies showed that MHT increased the risks of gynecological related tumors, cardiovascular and cerebrovascular diseases, which limited the clinical application of MHT and prevented some patients who need MHT from getting timely treatment. However, with the standardization of therapeutic schedule, the effectiveness and safety of MHT application have been greatly improved. This article summarizes the current clinical research results together with the benefits and risks of MHT. Key words: Menopause; Menopause hormone therapy; Tumors; Cardiovascular and cerebrovascular diseases