lncRNA MALAT1在胶质瘤中的功能作用

IF 0.4 Q4 ONCOLOGY

Current Cancer Therapy Reviews Pub Date : 2023-07-20 DOI:10.2174/1573394719666230720164009

M. Farzaneh, S. Khoshnam, Arya Moftakhar, Sajad Najafi, Omid Anbiyaee

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引用次数: 0

摘要

胶质瘤是一类具有多种临床和生物学特征的脑癌，多为恶性肿瘤。治疗方法的进展，包括放疗、化疗和手术，在胶质瘤病例的预后中并没有那么显著。近年来，人们发现长链非编码rna (lncRNAs)在基因表达、表观遗传调控、神经发生、细胞周期和细胞运输等方面都有可能发挥调控作用。lncRNA转移相关肺腺癌转录本1 (MALAT1)经常被报道与多种疾病，如各种类型的癌症相关。MALAT1在包括胶质瘤在内的不同肿瘤中均有表达上调，功能分析显示它影响癌细胞的增殖、迁移、侵袭和凋亡等恶性特征。MALAT1通过调节各种表观遗传组蛋白、激素、生长因子和转录因子来影响这些特征。因此，该lncRNA可被视为胶质瘤的有效治疗靶点。本文就MALAT1在胶质瘤中的功能作用作一综述。

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Functional roles of the lncRNA MALAT1 in glioma

Gliomas are a group of brain cancers with various clinical and biological features, and they are mostly malignant. Progressions in therapy approaches, comprising radiotherapy, chemotherapy, and surgery, have not been so considerable in the prognosis of glioma cases. Recently, long non-coding RNAs (lncRNAs) have been found with putative regulatory roles in gene expression, epigenetic regulation, neurogenesis, cell cycle, and cellular transportation. The lncRNA Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is frequently reported to be associated with multiple disorders, such as various types of cancers. Upregulation of MALAT1 is detected in different tumours, including glioma, and functional analyses reveal it affects malignant features of cancer cells like proliferation, migration, invasion and apoptosis. MALAT1 impacts those features by modulating various epigenetic histones, hormones, growth factors, and transcription factors. Therefore, this lncRNA can be regarded as a potent therapeutic target for glioma. In this review, we summarized the functional roles of MALAT1 in glioma.

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来源期刊

Current Cancer Therapy Reviews ONCOLOGY-

CiteScore

1.00

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0.00%

发文量

期刊介绍： Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.