谷草根醇提液和水提液的植物化学分析及抗氧化和抗炎活性研究。来自科特迪瓦的前DC

Sylla Tahiri, M’bra Kouassi Fulgence, Dongui Bini Kouame
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引用次数: 1

摘要

本研究考察了黄的根(乙醇和水)提取物的植物化学、抗氧化和抗炎潜力。使用体外DPPH自由基清除活性测定法测定它们的抗氧化活性。乙醇提取物的IC50最低(0.055 mg/mL),与维生素C相当。提取物的植物化学筛选显示存在甾醇和多萜、多酚、生物碱、类黄酮、儿茶素单宁、没食子单宁、皂化苷、萜类、粘液、花青素、挥发油和强心苷。提取物显著抑制卡拉胶引起的足跖水肿的发展。抗炎研究表明,在最初的几个小时内,200mg/kg体重的所有提取物的炎症抑制潜力都显著低于标准双氯芬酸(20mg/kg)。在第3小时,乙醇提取物和水提取物的炎症抑制潜力显著高于标准品。这项研究表明,黄提取物具有抗炎作用,可以作为一种有效的抗氧化剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire
The phytochemical, antioxidant, and anti-inflammatory potential of root (ethanol and aqueous) extracts of Combretum glutinosum was investigated in this study. Their antioxidant activity was determined using an in vitro DPPH radical scavenging activity assay. The ethanol extract had the lowest IC50 (0.055 mg/mL), which is comparable to vitamin C. Phytochemical screening of extracts revealed the presence of sterols and polyterpenes, polyphenols, alkaloids, flavonoids, catechin tannins, gallic tannins, saponosides, terpenoids, mucilages, anthocyanins, volatile oils, and cardiac glycosides. The extracts significantly inhibit the development of paw edema induced by carrageenan. Anti-inflammatory studies showed that the inflammation inhibition potential of 200 mg/kg body weight of all extracts was significantly lower than the standard diclofenac (20 mg/kg) in the first hours. At the third hour, the inflammation inhibition potential of ethanolic and aqueous extracts was significantly higher than that of the standard. This study revealed that Combretum glutinosum extracts have anti-inflammatory effects and can act as an effective antioxidant.
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