我们准备好进行猪到人的临床异种移植试验了吗?

IF 0.5 4区哲学 Q4 ETHICS

Acta Bioethica Pub Date : 2022-06-01 DOI:10.4067/s1726-569x2022000100149

Laichun Zhang, L. Ling

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引用次数: 0

摘要

异体器官移植的发明和广泛应用为一些原胎儿疾病如肝/肾功能衰竭提供了有效的治疗，并在全球挽救了数百万人的生命。然而，人体器官的稀缺导致世界各地许多本可以接受治疗的患者在等待合适器官的过程中死亡。猪到人的异种移植为解决这一棘手问题提供了一个潜在的解决方案。猪器官被认为是异种器官移植的主要来源，因为供体数量充足，器官大小，生理结构相似。然而，异种器官移植也存在一些问题，如动物疾病传播给人类的可能性、种间免疫屏障、动物来源的器官挑战人性以及潜在的知情同意问题。本文将讨论这些潜在的问题，并看看现在是否适合在人类中进行临床异种移植试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Are we ready for pig-to-human clinical xenotransplantation trials?

: The invention and widely use of organ allotransplantation provides effective treatment of some originally fetal diseases such as liver/kidney failure and has saved million of lives around the globe. However, the scarcity of human organs has caused many patients, who could have been treated, to die while waiting for suitable organs around the world. Pig-to hu- man xenotransplantation provides a potential solution to solve this tough problem. Pig organs have been considered as major sources of xenotransplantation because of the sufficient number of donors, the sizes of organs, and physiologically structural similarities. However, xenotransplantation also has some problems, such as the possibility of spreading animal diseases to human, the interspecies immunological barrier, organs of animal origin challenging human nature, and potential informed consent issues. This article will discuss these potential issues and to see whether it is the suitable time to conduct clinical xenotransplantation trials in humans.

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来源期刊

Acta Bioethica Bioethical Issues-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Acta Bioethica is a biannual publication by the Interdisciplinary Center for Studies in Bioethics of the University of Chile (ISSN 0717-5906, press edition, y 1726-569-X, electronic edition), which publishes in three languages: Spanish, English and Portuguese. Indexed in Science Citation Index (SCI), Scopus, Lilacs, SciELO y Latindex, and in database from several Institutions; it constitutes a pluralistic source of perspectives and an important tribune which accepts the contributions of authors compromised with the interdisciplinary study of ethical determinants and consequences of techno scientific research.