Juliet Alla, Joshua P Nickerson, MD, Matthew Wood, MD, PhD, M. Mossa-Basha, Christopher G Filippi, D. Zarnow, Jianling Ji, MD, Jaclyn A Biegel, PhD, Yassmine Akkari, PhD, Gisele Ishak, MD, R. Barajas
{"title":"ETV6-NTRK3基因融合的高级别胶质瘤影像学表现与病理相关性","authors":"Juliet Alla, Joshua P Nickerson, MD, Matthew Wood, MD, PhD, M. Mossa-Basha, Christopher G Filippi, D. Zarnow, Jianling Ji, MD, Jaclyn A Biegel, PhD, Yassmine Akkari, PhD, Gisele Ishak, MD, R. Barajas","doi":"10.26226/morressier.5e5e70e335f8e2df5e55a68c","DOIUrl":null,"url":null,"abstract":"Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive‐appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted\n therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.","PeriodicalId":36193,"journal":{"name":"Neurographics","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-grade Glial Tumors Associated with ETV6-NTRK3 Gene Fusion: Imaging Appearance with Pathological Correlate\",\"authors\":\"Juliet Alla, Joshua P Nickerson, MD, Matthew Wood, MD, PhD, M. Mossa-Basha, Christopher G Filippi, D. Zarnow, Jianling Ji, MD, Jaclyn A Biegel, PhD, Yassmine Akkari, PhD, Gisele Ishak, MD, R. Barajas\",\"doi\":\"10.26226/morressier.5e5e70e335f8e2df5e55a68c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive‐appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted\\n therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.\",\"PeriodicalId\":36193,\"journal\":{\"name\":\"Neurographics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-04-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neurographics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26226/morressier.5e5e70e335f8e2df5e55a68c\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurographics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26226/morressier.5e5e70e335f8e2df5e55a68c","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
High-grade Glial Tumors Associated with ETV6-NTRK3 Gene Fusion: Imaging Appearance with Pathological Correlate
Genetic analysis of high-grade glial tumors in children has revealed the presence of the ETV6-NTRK3 gene fusion in a small number of highly aggressive‐appearing neoplasms. Identification of this gene fusion is important in that these patients may benefit from new, targeted
therapies. Clinical presentation, imaging, and pathologic confirmation were obtained from 5 patients with confirmed ETV6-NTRK3 gene fusion. This case series may raise awareness of this entity and prompt genetic evaluation.
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