子宫自噬的调控:从生理过程到子宫内膜异位症和子宫肌瘤

F&S reviews Pub Date : 2022-01-01 DOI:10.1016/j.xfnr.2021.11.003

Paola Marcolongo Ph.D. , Emilia Maellaro Ph.D. , Stefano Luisi M.D., Ph.D.

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引用次数: 2

摘要

子宫内膜异位症和子宫肌瘤是两种常见的妇科疾病。尽管已经确定了几种不同的危险因素，包括遗传易感性、激素和促炎细胞因子，但其病理生理学尚不清楚。本文概述了自噬在子宫内膜和子宫肌层生理学中的作用的实验证据，以及自噬可能有助于子宫内膜异位症和子宫肌瘤发病的新证据。对自噬作用的完整定义可能会导致对这些疾病有效的新药物治疗。

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Regulation of autophagy in the uterus: from physiological processes to endometriosis and uterine fibroids

Endometriosis and uterine fibroids are 2 common gynecological disorders. Their pathophysiology remains unclear, although several different risk factors have been identified, including genetic predisposition, hormones, and proinflammatory cytokines. The present review outlines the experimental evidence showing the role of autophagy in the physiology of the endometrium and myometrium and emerging evidence that autophagy may contribute to the onset of endometriosis and uterine fibroids. The full definition of the role of autophagy is likely to lead to effective new pharmacologic treatments for these disorders.

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来源期刊

F&S reviews Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

61 days