高血压的时间药理学——临床证据的重要回顾

European Pharmaceutical Journal Pub Date : 2019-11-01 DOI:10.2478/afpuc-2019-0017

P. Potúček, J. Klimas

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引用次数: 3

摘要

摘要心血管系统的生理功能表现出受复杂的内源性因子系统调节的昼夜节律模式。保持这种节律性对其正常功能很重要，而干扰与自然昼夜周期的同步会增加心血管损伤的风险。心血管病理生理学也遵循周期性变化；可以预测与血压升高（BP）相关的时间易感性和具有最大风险的时期。鉴于这种节律性，药物早晚给药之间的疗效可能会发生显著变化；药物干预治疗高血压的适当时机可能会影响治疗效果。

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Chronopharmacology of high blood pressure—a critical review of clinical evidence

Abstract Physiological functions of cardiovascular system (CVS) are exhibiting circadian patterns regulated by complex system of endogenous factors. Preserving this rhythmicity is important for its normal function, whereas disturbing the synchronization with natural day–night cycle can increase the risk of cardiovascular damage. Cardiovascular pathophysiology also follows cyclic variation; time susceptibility and period with maximum risk associated with elevated blood pressure (BP) can be predicted. Given this rhythmic nature, significant changes in efficacy between morning and evening administration of the drug may occur; appropriate timing of pharmacological intervention in therapy of hypertension may affect the efficacy of the treatment.

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.