{"title":"TMEM251，溶酶体酶运输的新参与者","authors":"Liming Wang, Han-Ming Shen","doi":"10.1093/lifemeta/loac039","DOIUrl":null,"url":null,"abstract":"\n In recent studies published in Science and Nature Communications, three independent groups identified TMEM251, one transmembrane protein in Golgi, is an indispensable factor for lysosomal enzyme trafficking. Loss or mutation of TMEM251 results in hypersecretion of lysosomal enzymes due to lack of mannose-6-phosphate (M6P) modification, leading to lysosomal dysfunction and eventually lysosome storage disorders (LSDs).","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TMEM251, a new player in lysosomal enzyme trafficking\",\"authors\":\"Liming Wang, Han-Ming Shen\",\"doi\":\"10.1093/lifemeta/loac039\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n In recent studies published in Science and Nature Communications, three independent groups identified TMEM251, one transmembrane protein in Golgi, is an indispensable factor for lysosomal enzyme trafficking. Loss or mutation of TMEM251 results in hypersecretion of lysosomal enzymes due to lack of mannose-6-phosphate (M6P) modification, leading to lysosomal dysfunction and eventually lysosome storage disorders (LSDs).\",\"PeriodicalId\":74074,\"journal\":{\"name\":\"Life metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Life metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/lifemeta/loac039\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/lifemeta/loac039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
TMEM251, a new player in lysosomal enzyme trafficking
In recent studies published in Science and Nature Communications, three independent groups identified TMEM251, one transmembrane protein in Golgi, is an indispensable factor for lysosomal enzyme trafficking. Loss or mutation of TMEM251 results in hypersecretion of lysosomal enzymes due to lack of mannose-6-phosphate (M6P) modification, leading to lysosomal dysfunction and eventually lysosome storage disorders (LSDs).
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