金丝桃科补骨孢子粉中一个新的苯丙类糖苷

IF 1.6 Q3 URBAN STUDIES

TOWN PLANNING REVIEW Pub Date : 2021-03-01 DOI:10.30495/TPR.2021.680493

G. Happi, A. Mbobda, M. Frese, S. Kouam, J. Tchouankeu, B. Lenta, N. Sewald

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引用次数: 5

摘要

从牛皮提取物中分离到一个新的苯基丙苷，命名为牛皮皂苷(1)。利用光谱和光谱分析方法(包括1D、2d nmr和ESI-MS)对它们的结构进行了鉴定，并与文献报道的数据进行了比较。对分离得到的化合物进行了对人宫颈癌细胞株KB3-1的细胞毒性评价。大黄素(2)及其同族2-香叶香茅素(3)表现出显著的细胞毒性，IC50值分别为11.4µM和19.0µM。此外，还讨论了分离化合物的化学分类意义。

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A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae)

A new phenylpropanoid glycoside named psorospermoside (1) possessing an allose unit was isolated from the Psorospermum tenuifolium Hook f. bark extract together with eleven known compounds. Their structures were elucidated using spectroscopic and spectrometric methods including 1D, 2D-NMR, and ESI-MS, as well as by comparison of their data with those reported in the literature. All the isolated compounds were assessed for their cytotoxicity effect on the human cervix carcinoma cell line KB3-1. Emodin (2) and its congener 2-geranylemodin (3) displayed significant cytotoxicity with IC50 values of 11.4 µM and 19.0µM, respectively. Furthermore, the chemotaxonomic significance of the isolated compounds was also discussed.

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来源期刊

TOWN PLANNING REVIEW URBAN STUDIES-

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： Town Planning Review has been one of the world"s leading journals of urban and regional planning since its foundation in 1910. With an extensive international readership, TPR is a well established urban and regional planning journal, providing a principal forum for communication between researchers and students, policy analysts and practitioners. To mark TPR’s centenary in 2010, it is proposed to publish a series of ‘Centenary Papers’ -- review papers that record and reflect on the state of the art in a range of topics in the general field of town and regional planning.