2型糖尿病合并和非糖尿病肾病患者血清IL-1水平的评估

IF 1.3 4区计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS

Journal of Database Management Pub Date : 2018-05-24 DOI:10.4236/jdm.2018.82006

Nahid Niknami, Melody Omraninava, Nazanin Mirzaei

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引用次数: 2

摘要

背景：糖尿病肾病（DN）已被认为是2型糖尿病（T2D）患者发病的重要原因。免疫系统成分在T2D期间受到调节，脂肪组织、胰岛、肝脏和循环白细胞的变化最为明显。本研究的目的是评估IL-1在肾病性T2D发病机制中的作用。方法：在本病例对照研究中，研究人群包括58例有蛋白尿的T2D患者（肾病T2D病例）作为病例组，76例无蛋白尿的T2 D患者（非肾病T2D患者）作为对照组。从所有个体获得血液样本，并进行ELISA方法来测量样本中的IL-1水平。结果：我们的实验表明，与没有肾病的T2D患者相比，患有肾病的T2D患者血液中的IL-1水平显著升高。结论：IL-1似乎在T2D患者肾病的发病机制中发挥作用，需要进一步实施，以生动地揭示这方面的炎症。

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Evaluation of the Serum Levels of IL-1 in Type 2 Diabetic Patients with and without Diabetic Nephropathy

Background: Diabetic nephropathy (DN) has been regarded as an important cause of morbidity in patients with type 2 diabetes (T2D). Immune system components are modulated during T2D, with the most apparent modifications in adipose tissue, pancreatic islets, liver, and circulating leukocytes. The aim of this survey was to evaluate the role of IL-1 in the etiopathogenesis of nephropathic T2D. Methods: In this case-control investigation, the study population consisted of 58 T2D patients with proteinuria (nephropathy T2D cases) as the case group and 76 T2D cases without proteinuria (non-nephropathy T2D cases) as the control group. Blood samples were obtained from all individuals and ELISA approach was carried out to measure IL-1 levels in samples. Results: Our experiments demonstrated that T2D patients with nephropathy had significantly increased levels of IL-1 in their blood in comparison to T2D patients without nephropathy. Conclusions: It seems that IL-1 plays a role in the etiopathogenesis of nephropathy in T2D patients, requiring further implementation to vivid disclose of the inflammation in this context.

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来源期刊

Journal of Database Management 工程技术-计算机：软件工程

CiteScore

4.20

自引率

23.10%

发文量

期刊介绍： The Journal of Database Management (JDM) publishes original research on all aspects of database management, design science, systems analysis and design, and software engineering. The primary mission of JDM is to be instrumental in the improvement and development of theory and practice related to information technology, information systems, and management of knowledge resources. The journal is targeted at both academic researchers and practicing IT professionals.