复心汤通过氧化抑制和调节免疫应答减轻阿霉素诱导的大鼠心力衰竭

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Guo Yuhong , Di Tingting , Zhao Jingxia , Xu Xiaolong , Li Ping , Huang Lijuan , Liu Qingquan
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引用次数: 5

摘要

目的观察复心汤对阿霉素致心力衰竭大鼠的影响。方法采用阿霉素致心衰模型,观察复心汤对心衰的影响。大鼠口服复心汤10 ~ 40 mg/kg。通过组织学评估组织结构变化,通过酶联免疫吸附法检测氧化应激相关生物标志物和炎症细胞因子的循环水平。结果复心汤能改善盐酸阿霉素注射大鼠的生长迟缓。复心汤可减轻大鼠心脏受累,并改变其充血系统循环。复心汤对盐酸阿霉素诱导的大鼠免疫反应有调节作用,对氧化反应有抑制作用。结论复心汤可能是治疗充血性心力衰竭的有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fuxin decoction attenuates doxorubicin-induced heart failure in rats via oxidizing suppression and regulating immune responses

OBJECTIVE

To observe the effects of Fuxin decoction in rats with heart failure induced by doxorubicin injections.

METHODS

We employed a doxorubicin-induced heart failure model to investigate the effect of Fuxin decoction. Rats were orally administered with Fuxin decoction from 10 to 40 mg/kg. Organization structure changes were assessed by histology, circulating levels of oxidative stress-related biomarkers and inflammatory cytokines were detected via enzyme-linked immunosorbent assay.

RESULTS

Administration of Fuxin decoction improved the growth retardation in doxorubicin hydrochloride injection rats. Cardiac involvement was alleviated by Fuxin decoction, as well as changes of congestion systemic circulation in this rat models. Furthermore, Fuxin decoction regulates immune responses and suppresses oxidation reaction in doxorubicin hydrochloride-induced rats.

CONCLUSION

Fuxin decoction might be an interesting candidate for congestive heart failure.

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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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