基于价值的摄食决策评估果蝇的认知状态

IF 5.4 Q1 GERIATRICS & GERONTOLOGY

NPJ Aging and Mechanisms of Disease Pub Date : 2020-08-27 DOI:10.1101/2020.08.27.267955

C. Yu, Ferng-Chang Chang, Yong-Huei Hong, Jian-Chiuan Li, Po-Lin Chen, Chun-Hong Chen, Tzai-Wen Chiu, Tsai‐Te Lu, Yun-Ming Wang, Chih-Fei Kao

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引用次数: 3

摘要

决策被认为是认知功能的一个重要方面。决策能力受损是由各种生理条件(如衰老和神经退行性疾病)引起的认知能力下降的结果。在这里，我们利用基于价值的喂养决策(VBFD)测定，这是一个简单的感觉-运动任务，以确定果蝇的认知状态。我们的研究结果表明，VBFD的恶化与衰老和神经退行性疾病显著相关。蘑菇体(MB)神经元活动的限制在一定程度上削弱了适当的VBFD。此外，利用果蝇多q疾病模型，我们证明了受损的VBFD可以通过二硝基铁络合物(DNIC-1)来改善，二硝基铁络合物是一种新型且稳定的一氧化氮(NO)释放化合物。因此，我们建议VBFD检测提供了果蝇认知的可靠评估，并可用于表征额外的神经保护干预措施。

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Assessing the cognitive status of Drosophila by the value-based feeding decision

Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cognitive status of Drosophila . Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.

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来源期刊

NPJ Aging and Mechanisms of Disease Medicine-Geriatrics and Gerontology

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms behind aging and the associated diseases. The journal’s scope includes, but is not restricted to, the following areas (not listed in order of preference): • cellular and molecular mechanisms of aging and aging-related diseases • interventions to affect the process of aging and longevity • homeostatic regulation and aging • age-associated complications • translational research into prevention and treatment of aging-related diseases • mechanistic bases for epidemiological aspects of aging-related disease.