微小RNA在呼吸道病毒中作为生物标志物和治疗靶点的潜力：文献综述。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2022-06-01 DOI:10.1089/dna.2021.1101

Omid Kooshkaki, A. Asghari, R. Mahdavi, Ghodsiyeh Azarkar, N. Parsamanesh

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引用次数: 2

摘要

MicroRNAs (miRNAs)是一种小的非编码rna，通过识别同源序列和干扰转录、翻译或表观遗传过程来调节基因表达。在不同的病毒中发现了数百种miRNA基因，其中许多在系统发育上是保守的。呼吸道病毒是人类最常见的致病因子，对全世界的发病率和死亡率有重大影响。近年来，mirna在呼吸道病毒基因调控以及疾病进展过程中宿主基因调控中的作用已成为人们关注的领域。这篇综述强调了各种mirna的重要性及其作为治疗分子在对抗呼吸道病毒中的潜在作用，重点是COVID-19。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Potential of MicroRNAs As Biomarkers and Therapeutic Targets in Respiratory Viruses: A Literature Review.

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression through recognition of cognate sequences and interference of transcriptional, translational, or epigenetic processes. Hundreds of miRNA genes have been found in diverse viruses, and many of these are phylogenetically conserved. Respiratory viruses are the most frequent causative agents of disease in humans, with a significant impact on morbidity and mortality worldwide. Recently, the role of miRNAs in respiratory viral gene regulation, as well as host gene regulation during disease progression, has become a field of interest. This review highlighted the importance of various miRNAs and their potential role in fighting with respiratory viruses as therapeutic molecules with a focus on COVID-19.

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.