尿道内应用安纳托利亚蜂胶提取物对大鼠尿道愈合的影响

IF 0.8 Q4 UROLOGY & NEPHROLOGY
R. Girgin, Emine Can, Gökhan Çeker, E. Kaymaz, Ö. Çınar, N. Mungan
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引用次数: 0

摘要

目的:尿道狭窄可能导致不可逆的结果,因为它阻止了正常的排尿。尽管有各种内镜和开放式手术选择,但结果并不总是令人满意,因此主要目的是防止尿道瘢痕的形成。我们的目的是检验经尿道给药安纳托利亚蜂胶对实验性尿道损伤后愈合的影响。材料与方法:选用Wistar雄性大鼠40只。将大鼠分为五个相等的组:健康对照组(第1组)、尿道损伤/病理组(第2组)、溶剂控制组(第3组)、为期1周的蜂胶治疗组(第4组)和为期3周的蜂胶处理组(第5组)。使用29G针头进行尿道损伤。溶剂对照组给予尿道内50%乙醇,第3组和第4组给予大鼠尿道内30%蜂胶。在深度麻醉下取阴茎组织,并在光学显微镜下检查。结果:除1只大鼠外,第2组尿道上皮和结缔组织均出现不规则和管腔狭窄。类似地,除一只大鼠外,在所有大鼠中都观察到充血性出血。除2只大鼠外,第3组尿道上皮和结缔组织出现不规则和充血。在一只大鼠中观察到完全改善,在第2组和第3组中的四只大鼠观察到超过50%的纤维化。在第4组中,在4只大鼠的尿道上皮中观察到不规则,而在5只大鼠中没有发现炎症。所有大鼠的纤维化均<50%。在第5组中,6只大鼠完全恢复,纤维化<30%。结论:将安纳托利亚蜂胶应用于尿道可加速尿道创伤后的恢复,减少纤维化的形成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of intraurethrally applied anatolian propolis extract on urethral healing in a rat model
Purpose: Urethral stricture may cause irreversible results, as it prevents normal voiding. Although various endoscopic and open surgical options are available, the results are not always satisfactory so the main purpose is to prevent the formation of urethral scar. Our purpose was to examine the effects of intraurethrally administered Anatolian propolis on healing after an experimental urethral injury. Materials and Methods: A total of 40 Wistar male rats were used. Rats were divided into five equal groups: healthy control (Group 1), urethral damage/pathology (Group 2), solvent control (Group 3), 1-week propolis treatment (Group 4) and 3-week propolis treatment (Group 5). Urethral damage was performed with a 29G needle. Intraurethral, 50% ethanol, was administered in the solvent control group and 30% propolis was administered intraurethrally to the rats in Groups 3 and 4. Penile tissues were taken under deep anesthesia and examined under a light microscope. Results: Irregularities and luminal narrowing in the urethral epithelium and connective tissue were found in Group 2, except for one rat. Similarly, hyperemia-bleeding was observed in all rats except for one rat. Irregularities and hyperemia in the urethral epithelium and connective tissue were found in Group 3, except for two rats. Total improvement was observed in one rat, and more than 50% of fibrosis was observed in four rats in Groups 2 and 3. In Group 4, irregularity was observed in the urethral epithelium in four rats, while no inflammation was found in five rats. All of the rats had <50% fibrosis. In Group 5, six rats had complete recovery and <30% fibrosis. Conclusion: Anatolian propolis applied into the urethra seems to accelerate recovery after urethral trauma and reduces the formation of fibrosis.
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来源期刊
Urological Science
Urological Science UROLOGY & NEPHROLOGY-
CiteScore
1.20
自引率
0.00%
发文量
26
审稿时长
6 weeks
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