CD200作为区分CLL和其他B细胞淋巴增生性疾病的有价值标志物

Pub Date : 2022-04-25 DOI:10.31901/24566330.2022/22.02.812

Noha Elnagdy

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引用次数: 0

摘要

慢性淋巴细胞白血病（CLL）是成熟B细胞淋巴肿瘤最常见的亚型，需要与其他B慢性淋巴增生性疾病（BCLPD）正确区分。CD200是CLL预后和诊断的重要标志物。用八色流式细胞术评估60例诊断为BCLPD的患者的CD200表达。将改良Matutes评分和CD200积分应用于CLL诊断。本研究中CLL患者的总体免疫表型显示CD5、CD22、CD23、CD43和CD200的显著、频繁表达。非典型和典型CLL患者的表型比较显示，非典型CLL患者CD5和CD43的表达显著较低，CD79b的表达较高。CD200在CLL患者（典型和非典型）中的表达显著高于MCL患者，后者仅在25%的患者中表现出微弱的CD200表达。CD200在诊断标记物中的包含可以增强CLL的改良Matutes评分准确性。

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CD200 as a Valuable Marker for Differentiating between CLL and Other B-cell Lymph Proliferative Disorders

Chronic lymphocytic leukaemia (CLL) being the commonest subtype of mature B-cell lymphoid neoplasms need to be differentiated correctly from other B-chronic lymphoproliferative disorders (BCLPD). CD200 is being an essential marker for prognosis and diagnosis of CLL. Sixty patients diagnosed with BCLPD were evaluated for CD200 expression with eight-colour flow cytometry. An integration of modified Matutes score and CD200 were applied for CLL diagnosis. The overall immunophenotype of CLL patients in this study showed significant, frequent expression of CD5, CD22, CD23, CD43 and CD200. Atypical versus typical CLL patients’ phenotype comparison revealed significant lower expression of CD5 and CD43 with higher expression of CD79b in atypical CLL patients. CD200 was expressed significantly higher in CLL patients (typical and atypical) than in MCL patients who showed dim CD200 expression in only twenty-five percent of patients. The inclusion of CD200 within the diagnostic markers can empower the modified Matutes score accuracy for CLL.

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