人绒毛膜促性腺激素重组疫苗进行免疫原性、安全性和有效性联合临床试验

G. Talwar
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引用次数: 0

摘要

此前,[1]等人开发了一种化学合成的疫苗,诱导抗人绒毛膜促性腺激素(hCG)抗体,该疫苗在性活跃女性中成功进行了I期和II期疗效临床试验,显示其能够在不影响排卵、激素谱和月经规律的情况下预防怀孕(表1)。该疫苗的疗效很高,每1224个周期只有一次怀孕。这是完全可逆的,希望再生孩子的妇女很容易在抗体低于20ng/ ml结合能力[2]的情况下怀孕。先前接种过疫苗的妇女所生的后代具有与其兄弟姐妹相似的发育标志和认知能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Recombinant Vaccine against Human Chorionic Gonadotropin goes on Combined Immunogenicity, Safety and Efficacy Clinical Trials
A chemically synthesized vaccine inducing antibodies against human chorionic gonadotropin (hCG) was previously developed by et al. [1] which had undergone successfully Phase I and Phase II efficacy Clinical trials in sexually active women showing its ability to prevent pregnancy without derangement of ovulation,hormonal profiles and menstrual regularity (Table 1). It had high efficacy with only one pregnancy occurring in 1224 cycles. It was fully reversible and women desirous of having another child conceived readily on antibodies falling below 20ng/ ml binding capacity [2]. The progeny born to previously immunized women had developmental land marks and cognitive abilities similar to their siblings [3].
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