微针辅助外用博来霉素治疗皮肤疣后巨噬细胞迁移抑制因子的血清水平

IF 0.2 Q4 DERMATOLOGY
Noha Z Tawfik, Ghada S. Mahmoud, H. Omar, A. Gomaa
{"title":"微针辅助外用博来霉素治疗皮肤疣后巨噬细胞迁移抑制因子的血清水平","authors":"Noha Z Tawfik, Ghada S. Mahmoud, H. Omar, A. Gomaa","doi":"10.4103/ejdv.ejdv_47_21","DOIUrl":null,"url":null,"abstract":"Background Plantar warts are a common viral infection affecting adults and children. Many studies concerning bleomycin show discrepancies in cure rates. Macrophage migration inhibitory factor (MIF) plays an important role in the skin regarding inflammation and immune response. However, little is known about its relation to cutaneous warts. Aim To assess serum MIF levels in patients with common warts before and after treatment by microneedling-assisted topical bleomycin (MATB). Patients and methods This quasi experimental study included 33 patients with cutaneous warts treated by MATB. MIF levels were assessed before and after treatment. Results The mean serum MIF level was significantly lower before bleomycin treatment and increased after treatment. Conclusion The serum MIF has a role in the immunity against human papillomavirus infection and MATB is a promising noninvasive therapeutic modality for cutaneous warts.","PeriodicalId":40542,"journal":{"name":"Egyptian Journal of Dermatology and Venereology","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum levels of macrophage migration inhibitory factor in cutaneous warts after microneedling-assisted topical bleomycin as a novel modality\",\"authors\":\"Noha Z Tawfik, Ghada S. Mahmoud, H. Omar, A. Gomaa\",\"doi\":\"10.4103/ejdv.ejdv_47_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Plantar warts are a common viral infection affecting adults and children. Many studies concerning bleomycin show discrepancies in cure rates. Macrophage migration inhibitory factor (MIF) plays an important role in the skin regarding inflammation and immune response. However, little is known about its relation to cutaneous warts. Aim To assess serum MIF levels in patients with common warts before and after treatment by microneedling-assisted topical bleomycin (MATB). Patients and methods This quasi experimental study included 33 patients with cutaneous warts treated by MATB. MIF levels were assessed before and after treatment. Results The mean serum MIF level was significantly lower before bleomycin treatment and increased after treatment. Conclusion The serum MIF has a role in the immunity against human papillomavirus infection and MATB is a promising noninvasive therapeutic modality for cutaneous warts.\",\"PeriodicalId\":40542,\"journal\":{\"name\":\"Egyptian Journal of Dermatology and Venereology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Dermatology and Venereology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ejdv.ejdv_47_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Dermatology and Venereology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ejdv.ejdv_47_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

足底疣是一种常见的病毒感染,影响成人和儿童。许多关于博莱霉素的研究表明治愈率存在差异。巨噬细胞迁移抑制因子(Macrophage migration inhibitory factor, MIF)在皮肤炎症和免疫反应中起重要作用。然而,人们对其与皮肤疣的关系知之甚少。目的评价微针辅助外用博来霉素(MATB)治疗常见疣患者前后血清MIF水平。患者与方法本准实验研究纳入33例经MATB治疗的皮肤疣患者。在治疗前后评估MIF水平。结果博莱霉素治疗前患者血清平均MIF水平明显降低,治疗后升高。结论血清MIF对人乳头瘤病毒感染具有免疫作用,MATB是一种有前途的无创治疗皮肤疣的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum levels of macrophage migration inhibitory factor in cutaneous warts after microneedling-assisted topical bleomycin as a novel modality
Background Plantar warts are a common viral infection affecting adults and children. Many studies concerning bleomycin show discrepancies in cure rates. Macrophage migration inhibitory factor (MIF) plays an important role in the skin regarding inflammation and immune response. However, little is known about its relation to cutaneous warts. Aim To assess serum MIF levels in patients with common warts before and after treatment by microneedling-assisted topical bleomycin (MATB). Patients and methods This quasi experimental study included 33 patients with cutaneous warts treated by MATB. MIF levels were assessed before and after treatment. Results The mean serum MIF level was significantly lower before bleomycin treatment and increased after treatment. Conclusion The serum MIF has a role in the immunity against human papillomavirus infection and MATB is a promising noninvasive therapeutic modality for cutaneous warts.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
25.00%
发文量
26
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信