Hideko Kotani, K. Matsubara, T. Koshizuka, K. Nishiyama, H. Kaneko, Mie Tasaka, Takashi Sugiyama, T. Suzutani
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引用次数: 2
摘要
目的:阴道环境是预测早孕先兆流产和胎膜早破的重要因素。阴道人β -防御素-2 (HBD-2)是一种与先天免疫相关的主要抗菌肽，在保护下生殖道免受微生物侵害方面发挥着多种作用。本研究旨在评估阴道HBD-2作为监测孕妇阴道环境的生化标志物的有效性。方法:28名孕妇参与本研究。采集阴道分泌物标本测定Nugent评分，用阴道洗涤液(4 ml生理盐水)ELISA法测定HBD-2水平。结果:在妊娠早期，细菌性阴道病(BV)患者阴道HBD-2水平(42.1±19.8 pg/ml)明显低于无BV患者(350.1±68.7 pg/ml, P < 0.05)，胎膜早破患者(57.2±31.9)
Human β-defensin-2 as a biochemical indicator of vaginal environment in pregnant women
Aim: Vaginal environment is an important factor in predicting threatened abortion and premature rupture of membranes (PROM) in early pregnancy. Vaginal human β -defensin-2 (HBD-2), a main antimicrobial peptide associated with innate immunity, plays multiple roles to protect the lower genital tract from microbes. This study aimed to assess the usefulness of vaginal HBD-2 as a biochemical marker for monitoring the vaginal environment in pregnant women. Methods: Twenty-eight pregnant women were enrolled in this study. Vaginal secretion samples were collected to determine Nugent scores, and vaginal washing fluid (4 ml saline) was used to measure HBD-2 levels by ELISA. Results: In the first trimester, vaginal HBD-2 levels were significantly lower in patients with bacterial vaginosis (BV) (42.1 ± 19.8 pg/ml) compared to those without BV (350.1 ± 68.7 pg/ml, P < 0.05), and in patients with PROM (57.2 ± 31.9
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