丹参提取物的抗菌活性和生物活性测定

Q3 Chemistry

Journal of the Turkish Chemical Society, Section A: Chemistry Pub Date : 2019-05-15 DOI:10.18596/JOTCSA.463681

Sevim Küçük, P. Soyer, Y. Tunalı

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引用次数: 2

摘要

本研究以2016年采收的苜蓿(S alvia sclarea L.)为原料，用70%的MeOH浸泡Saricakaya (Eskisehir/Turkey)和干燥的药用植物材料。采用最小抑菌浓度法(MIC)测定丹参提取物对大肠杆菌ATCC 35218、金黄色葡萄球菌ATCC 29213和白色念珠菌ATCC 90028的抑菌活性。测定了丹参提取物对金黄色葡萄球菌ATCC 29213和表皮葡萄球菌ATCC 14990的抗菌活性。并采用盐水对虾致死试验初步评价了提取物对模式生物褐藻的细胞毒性。结果表明，丹参提取物对白色念珠菌ATCC 90028没有明显的抑菌作用。此外，抗菌膜活性也无法确定。由于剂量浓度高，致死效应也无法确定。

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Determination of Antimicrobial and Biological Activities of Salvia sclarea L. (Lamiaceae) Extracts

In the present study, S alvia sclarea L. was collected during to flowering stage in 2016, Saricakaya (Eskisehir/Turkey) and dried medicinal plant materials were macerated with 70% MeOH. The antimicrobial activity of Salvia sclarea extracts was determined with minimum inhibitory concentration (MIC) assay against Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 29213 and Candida albicans ATCC 90028. The antibiofilm activity of Salvia sclarea extracts was determined against Staphylococcus aureus ATCC 29213 and Staphylococcus epidermidis ATCC 14990. And the preliminary cytotoxicity assessment of extracts was tested with Brine Shrimp Lethality Assay against model organism Artemia salina nauplii. As a result, Salvia sclarea extract showed remarkably antibacterial activity while it showed no effect on Candida albicans ATCC 90028. Moreover, antibiofilm activity could not be determined. The lethality effect also could not be determined due to high dose concentrations.

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来源期刊

Journal of the Turkish Chemical Society, Section A: Chemistry Chemistry-Chemistry (all)

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

5 weeks