A. Hammad, Shaaban M. Gadallah, N. Thabet, T. Misk, A. Sharshar
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引用次数: 0
摘要
:站立镇静是马全身麻醉的有效替代品,有必要开发新的副作用最小的镇静组合。因此,本研究旨在研究甲苯噻嗪单独或与芬太尼或萘布芬联合用药对马某些血液生化参数的影响。5匹成年健康马被随机分配接受三种治疗,间隔1周,如下:XYL组(0.55 mg/kg G1的甲苯噻嗪IV);XYL/FEN组(0.55 mg kg G 1甲苯噻嗪IV和4.92µG kg G 1芬太尼IV)和XYL/NAL(0.55 mg/kg G 1甲苯吡嗪IV和0.3 mg/kg G 1萘布芬IV)。在甲苯噻嗪给药前(基线)和给药后8、15、30、60、90和120分钟采集静脉血样。所有研究变量均采用单因素方差分析(ANOVA)进行分析,显著性水平设定为p<0.05。红细胞计数(RBCs)、血红蛋白(Hb)浓度、堆积细胞体积(PCV%)显著降低,检测到甲苯噻嗪对红细胞指数、血小板计数以及血清TP和白蛋白浓度的抑制作用,但可能不建议糖尿病动物使用芬太尼/甲苯噻嗪组合。
Effect of Xylazine, Xylazine/Fentanyl and Xylazine/Nalbuphine on Hematological and Serum Biochemical Parameters in Standing Horses
: Standing sedation is an efficient alternative to general anesthesia in horses and a necessity is present for development of new sedative combinations with minimal adverse effects. Therefore, this study was designed to investigate the effect of xylazine given alone or in combination with fentanyl or nalbuphine on some hematobiochemical parameters in horses. Five adult healthy horses were randomly assigned to receive three treatments at 1 week interval as follows, XYL group (0.55 mg kg G 1 of xylazine IV); XYL/FEN group (0.55 mg kg G 1 of xylazine IV with 4.92 µg kg G 1 of fentanyl IV) and XYL/NAL (0.55 mg kg G 1 of xylazine IV with 0.3 mg kg G 1 of nalbuphine IV).Venous blood samples were collected before (baseline) and at 8, 15, 30, 60, 90 and 120 min after xylazine administration. All studied variables were analyzed using a one-way Analysis of Variance (ANOVA) and the level of significance was set at p<0.05. Significant decrease in Red Blood Cell Count (RBCs), Hemoglobin (Hb) concentrations, Packed Cell Volume (PCV%) was detected the depressant effect of xylazine on red blood cell indices, platelet counts and serum concentrations of TP and albumin, however, fentanyl/xylazine combination may be not recommended in diabetic animals.
期刊介绍:
Journal of Animal Veterinary advances is a peer-reviewed, open-access scientific journal which publishes articles related to experiments, treatment, analysis, biological elements and other methods of research connected with veterinary. JAVA started publishing activity in 2002, since that time is updated twice a month, and is available in online and print formats. The publications are reviewed by Editorial Board in accordance with the standards and novelty of the subject, while strictly following ethical guidelines. Subject areas suitable for publication include, but are not limited to the following fields :: Veterinary science :: Animal husbandry :: Animal nutrition :: Anatomy :: Biological science :: Pathology :: Infectious diseases :: Animal physiology :: Animal breeding :: Animal biotechnology :: Transgenic animal production :: Animal parasitology :: Veterinary medicine :: Animal feed and nutrition :: Equine.