{"title":"Mu阿片受体基因（OPRM1）调节父母关注对社会支持寻求的影响","authors":"Shaofeng Zheng, Keiko Ishii, Takahiko Masuda, Masahiro Matsunaga, Yasuki Noguchi, Hidenori Yamasue, Yohsuke Ohtsubo","doi":"10.1007/s40750-022-00192-w","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Caring, sensitive parenting is known to be associated with higher levels of engagement in support-seeking behaviors among children and young adolescents. However, no study has yet explored the role of perceived parental attention in social support seeking in early adulthood. Growing evidence suggests that the µ-opioid receptor gene polymorphism (<i>OPRM1</i> A118G) moderates one’s responsiveness to social environments. Prompted by the differential susceptibility theory of gene–environment interaction, the present study examined whether the <i>OPRM1</i> polymorphism would moderate the association between perceived parental attention and social support seeking in early adulthood.</p><h3>Methods</h3><p>Six hundred and twenty Japanese undergraduate students self-reported the amount of attention they subjectively perceived their parents to have given them during childhood and completed scales that assess support-seeking behaviors. Clippings of their fingernails were collected for genotyping.</p><h3>Results</h3><p>The results showed that the interactive effect of perceived parental attention and <i>OPRM1</i> genotypes on social support seeking was significant. Specifically, perceived parental attention only significantly and positively predicted <i>OPRM1</i> GG carriers’ social support seeking in response to stress.</p><h3>Conclusions</h3><p>The findings support the view that <i>OPRM1</i> polymorphism moderates the association between early experiences and developmental outcomes.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40750-022-00192-w.pdf","citationCount":"0","resultStr":"{\"title\":\"Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking\",\"authors\":\"Shaofeng Zheng, Keiko Ishii, Takahiko Masuda, Masahiro Matsunaga, Yasuki Noguchi, Hidenori Yamasue, Yohsuke Ohtsubo\",\"doi\":\"10.1007/s40750-022-00192-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Caring, sensitive parenting is known to be associated with higher levels of engagement in support-seeking behaviors among children and young adolescents. However, no study has yet explored the role of perceived parental attention in social support seeking in early adulthood. Growing evidence suggests that the µ-opioid receptor gene polymorphism (<i>OPRM1</i> A118G) moderates one’s responsiveness to social environments. Prompted by the differential susceptibility theory of gene–environment interaction, the present study examined whether the <i>OPRM1</i> polymorphism would moderate the association between perceived parental attention and social support seeking in early adulthood.</p><h3>Methods</h3><p>Six hundred and twenty Japanese undergraduate students self-reported the amount of attention they subjectively perceived their parents to have given them during childhood and completed scales that assess support-seeking behaviors. Clippings of their fingernails were collected for genotyping.</p><h3>Results</h3><p>The results showed that the interactive effect of perceived parental attention and <i>OPRM1</i> genotypes on social support seeking was significant. Specifically, perceived parental attention only significantly and positively predicted <i>OPRM1</i> GG carriers’ social support seeking in response to stress.</p><h3>Conclusions</h3><p>The findings support the view that <i>OPRM1</i> polymorphism moderates the association between early experiences and developmental outcomes.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2022-06-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s40750-022-00192-w.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40750-022-00192-w\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s40750-022-00192-w","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking
Objective
Caring, sensitive parenting is known to be associated with higher levels of engagement in support-seeking behaviors among children and young adolescents. However, no study has yet explored the role of perceived parental attention in social support seeking in early adulthood. Growing evidence suggests that the µ-opioid receptor gene polymorphism (OPRM1 A118G) moderates one’s responsiveness to social environments. Prompted by the differential susceptibility theory of gene–environment interaction, the present study examined whether the OPRM1 polymorphism would moderate the association between perceived parental attention and social support seeking in early adulthood.
Methods
Six hundred and twenty Japanese undergraduate students self-reported the amount of attention they subjectively perceived their parents to have given them during childhood and completed scales that assess support-seeking behaviors. Clippings of their fingernails were collected for genotyping.
Results
The results showed that the interactive effect of perceived parental attention and OPRM1 genotypes on social support seeking was significant. Specifically, perceived parental attention only significantly and positively predicted OPRM1 GG carriers’ social support seeking in response to stress.
Conclusions
The findings support the view that OPRM1 polymorphism moderates the association between early experiences and developmental outcomes.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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