IL-33/ST2轴对脂肪组织免疫细胞的调控作用及其与肥胖的关系

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-09-30 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.09.014

Zeng-jie Zhang, Y. Kai

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引用次数: 1

摘要

肥胖是一个备受全社会关注的健康问题。大量研究表明，肥胖可导致内脏脂肪组织中免疫细胞亚群和免疫分子的类型和数量发生变化，IL-33/ST2在维持免疫稳态中起着至关重要的作用。本文综述了近年来IL-33/ST2对脂肪组织中脂肪细胞和免疫细胞的调控作用，以及肥胖过程中脂肪组织和全身IL-33的变化。关键词:IL-33;ST2;脂肪;肥胖;免疫细胞

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Regulatory effects of IL-33/ST2 axis on adipose tissue immune cells and relationship to obesity

Obesity is a health problem of great concern to the whole society. Numerous studies have shown that obesity can lead to changes in the types and numbers of immune cell subsets and immune molecules in visceral adipose tissues, and IL-33/ST2 plays a crucial role in maintaining immune homeostasis. This paper reviewed the regulatory effects of IL-33/ST2 on adipocytes and immune cells in adipose tissues, as well as the changes of IL-33 in adipose tissues and the whole body during obesity in recent years. Key words: IL-33; ST2; Fat; Obesity; Immune cell

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.