新型药物7-（4-氟苄基）-3-硫氧基-2,3-二氢[1,2,4]三唑并[4,3-a]吡嗪-8（7H）酮的定量测定

IF 0.5 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Chemija Pub Date : 2021-02-27 DOI:10.6001/CHEMIJA.V32I1.4398

K. Netosova, O. Zavada, A. Materiienko, I. Zhuravel, Serhii Baiurka

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引用次数: 0

摘要

4哈尔科夫医学研究生教育学院临床生物化学、法医毒理学和药学系，地址：58 Amosova Street，61176 Kharkiv，乌克兰本文介绍了使用非水电位滴定法开发物质7-（4-氟苄基）-3-硫氧基-2,3-二氢-[1，2，4]三唑并[4，3-a]吡嗪-8（7H）酮定量方法的研究结果。已对所开发的方法进行了验证，确认了以下特性：线性、准确度和精密度符合这些措施的验收标准。

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Quantitative determination of the new substance 7-(4-fluorobenzyl)-3-thioxo-2,3-dihydro[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one as a potential pharmaceutical agent

4 Department of Clinical Biochemistry, Forensic Toxicology and Pharmacy, Kharkiv Medical Academy of Post-graduate Education, 58 Amosova Street, 61176 Kharkiv, Ukraine The article presents results of studies on the development of a quantification method for a substance 7-(4-fluorobenzyl)-3-thioxo-2,3-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one using the method of nonaqueous potentiometric titration. Validation of the developed method has been carried out confirming the following characteristics: linearity, accuracy and precision that match the acceptance criteria for these measures.

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来源期刊

Chemija 化学-化学综合

CiteScore

1.30

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： Chemija publishes original research articles and reviews from all branches of modern chemistry, including physical, inorganic, analytical, organic, polymer chemistry, electrochemistry, and multidisciplinary approaches.