c-TCD检测偏头痛患者左右分流与临床特征的关系

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2022-07-01 DOI:10.17712/nsj.2022.3.20210109

Zhe Shi, Yonghui Wu, Lei Su, Ying Zhou, Lan Zhang, Da Xu, Yangang Xing

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引用次数: 0

摘要

目的：探讨有先兆（MA+）或无先兆（MA-）偏头痛患者c-TCD检测的右向左分流（RLS）的存在或参数与发作临床特征之间的关系。方法：连续招募有先兆偏头痛患者和无先兆偏头痛患者（MA-）。RLS通过c-TCD检查进行评估。结果：共纳入528名偏头痛患者和71名健康人。偏头痛患者RLS的患病率较高，尤其是轻度分流。MA+患者更早出现偏头痛，并经历更严重的疼痛、更频繁的畏光和恐音，尽管每年的疼痛频率、持续时间和程度或分流的类型和大小相似。此外，患有MA+和RLS（MA+RLS+）的患者也比没有RLS（MA+RLS-）的患者经历了更多的畏光和恐音。MA-RLS+组的结果相似。在MA+RLS+和MA-RLS+组中，中度或重度RLS患者的疼痛持续时间更长。MA+RLS+组的性别分布只有显著差异，其中女性更容易患RLS，尤其是轻度分流。结论：RLS在偏头痛患者中的发生率和严重程度较高，尤其是有先兆的患者。MA+患者发展较早，并经历更严重的疼痛。持续时间与MA+RLS+和MA-RLS+组的分流大小一致。

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Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients

Objectives: To explore the relationship between the presence or parameters of right-to-left shunt (RLS) detected by c-TCD and attack clinical features in migraine patients with aura (MA+) or without aura (MA-). Methods: Migraine patients with aura and migraine patients without aura (MA-) were recruited consecutively. The RLS was assessed by a c-TCD examination. Results: A total of 528 migraine patients and 71 healthy were included. The prevalence of RLS especially of mild shunts was higher in patients with migraine. Patients of MA+ developed migraine earlier and experienced more severe pain, more frequent photophobia and phonophobia, although the yearly frequency, duration and degree of pain or type and size of shunt was similar. Moreover, patients with MA+ and RLS (MA+RLS+) also experienced more photophobia and phonophobia than that without RLS (MA+RLS-). The result was similar in MA-RLS+ group. Patients with moderate or massive of RLS experience longer duration of pain in both MA+RLS+ and MA-RLS+ groups. The sex distribution was only significantly different in MA+RLS+ group, in which women were more likely to suffer from RLS especially mild shunt. Conclusion: A higher prevalence and severity of RLS was found in the migraine patients, especially those with aura. MA+ patients develop earlier and experience more severe pain. The duration was consistent with the shunt size in both MA+RLS+ and MA-RLS+ groups.

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来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.