壳聚糖在以大分子化合物为基础制备皮肤用水凝胶中的应用

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2018-09-10 DOI:10.15259/PCACD.23.018

M. Szcześniak, B. Grimling, J. Meler, B. Karolewicz

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引用次数: 1

摘要

研究了壳聚糖浓度对2%甲基纤维素和10%聚乙烯吡咯烷酮皮肤病制剂性能的影响。随着壳聚糖、丙二醇-1，2和甘油含量的增加，亲水凝胶的硬度、稠度和内聚性增加，而耗散能力降低。与含有聚乙烯吡咯烷酮的配方相比，基于甲基纤维素和壳聚糖的凝胶具有更高的挥发性化合物损失率、更高的1,2-丙二醇配方pH值和更高的质地参数。测试的水凝胶具有良好的流变性能，可以从管中挤出并在皮肤上扩散。

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APPLICATION OF CHITOSAN IN THE FORMULATION OF DERMATOLOGICAL HYDROGELS PREPARED ON THE BASIS OF MACROMOLECULAR COMPOUNDS

The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.