2型糖尿病与非糖尿病人群肠道菌群的差异

Q4 Nursing

中华临床营养杂志 Pub Date : 2019-12-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2019.06.003

Shixuan Liu, Yong Xue, T. Yuan, Yong Fu, Naishi Li, Ying-yue Dong, B. Zhu

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引用次数: 0

摘要

目的探讨北京市2型糖尿病(T2DM)患者与非糖尿病人群肠道菌群的差异。方法选择T2DM患者83例作为T2DM组，非糖尿病患者64例作为对照组。收集了所有受试者的粪便样本。采用宏基因组测序技术检测肠道菌群。结果两组共检出11门细菌，其中放线菌门(P=0.013)、厚壁菌门(P=0.005)、梭菌门(P=0.001)、变形菌门(P<0.001)的物种多样性差异有统计学意义。T2DM组放线菌门、梭菌门、变形菌门均富集，对照组厚壁菌门富集。两组共检出152个细菌属，差异显著的细菌属有31个。T2DM组Roseburia、Eubacterium、Faecalibacterium水平降低，Bifidobacterium、Lactobacillus、Escherichia水平升高。结论2型糖尿病患者与非糖尿病人群肠道菌群组成存在显著差异。调节T2DM患者的肠道菌群可能有助于改善T2DM的病情。关键词:2型糖尿病;肠道微生物群;Metagenome分析

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Differences of gut microbiota between type 2 diabetes and non-diabetic population

Objective To explore the difference of gut microbiota between type 2 diabetes mellitus (T2DM) and non-diabetic population in Beijing. Methods 83 T2DM patients were selected as T2DM group and 64 non-diabetic subjects were selected as control group. Fecal samples were collected from all the subjects. The intestinal flora was detected by metagenome sequencing technology. Results 11 bacterialphyla were detected in the two groups, there were significant differences in species diversity of Actinobacteria(P=0.013), Firmicutes(P=0.005), Fusobacteria(P=0.001), Proteobacteria(P<0.001) between the two groups.Actinobacteria, Fusobacteria and Proteobacteria were all enriched in the T2DM group, Firmicutes were enriched in the control group. 152 bacterial genera were detected in the two groups with 31 bacterial genera ofsignificant differences. In T2DM group, the levels of Roseburia, Eubacterium and Faecalibacterium decreased, while the levels of Bifidobacterium, Lactobacillus and Escherichia increased. Conclusion There are significant differ-ences in the composition of gut microbiota between T2DM patients and non-diabetic population. Regulation of gut microbiota in T2DM patients may be helpful to improve the condition of T2DM. Key words: Type 2 diabetes; Gut microbiota; Metagenome analysis

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.